Relationships between the amount of saliva and medications in elderly individuals
Relationships between the amount of saliva and medications in elderly individuals
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DOI：
10.1111/j.1741-2358.2009.00358.x
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发表时间：
2011-06-01
期刊：
影响因子：
2
通讯作者：
Igarashi, Atsuko
中科院分区：
文献类型：
--
作者：
Ichikawa, Kana;Sakuma, Shihoko;Igarashi, Atsuko
目的：探讨老年人药物治疗与唾液分泌量的关系。背景资料：老年人口腔干燥可能是药物治疗的副作用。材料与方法：对368例79-80岁的老年人（男177例，女191例）进行了30 s（棉卷试验）和3 min（牙龈试验）的无刺激唾液分泌量测定。结果：未刺激和刺激唾液的平均体积分别为0.14 +/- 0.13和4.30 +/- 2.54 ml。性别和平均唾液量之间存在显着差异。男性未刺激唾液的体积为0.16 +/- 0.15 ml，女性为0.11 +/- 0.10 ml。男性刺激唾液的体积为4.99 +/- 2.67 ml，女性为3.67 +/- 2.25 ml。服用药物的受试者百分比为64.7%（238/368）。平均用药次数为2.08 +/- 2.26，性别间无显著差异（男性2.01 +/- 2.37，女性2.16 +/- 2.16）。在以唾液量为目标变量、药物种类数为解释变量的逐步多元回归分析中，除性别和药物种类数外，对非刺激性唾液量有显著解释作用的变量为抗凝剂、钙拮抗剂和消化性溃疡药物，对刺激性唾液量有显著解释作用的变量为糖尿病药物和消化性溃疡药物。这些研究结果表明，老年人的唾液量存在性别差异，唾液量受药物数量和类型的影响。
Objective:To investigate medications that are related to volume of saliva in the elderly.Background data:In the elderly, many cases of mouth dryness may represent side effects of medication.Materials and methods:The volume of unstimulated saliva was measured for 30 s (cotton roll test), and with stimulation for 3 min (gum test) in 368 subjects 79-80 years old (177 men, 191 women). Medications were investigated using subject's medication notebooks.Results:Mean volumes of unstimulated and stimulated saliva were 0.14 +/- 0.13 and 4.30 +/- 2.54 ml respectively. Significant differences were seen between gender and mean volume of saliva. The volume of unstimulated saliva was 0.16 +/- 0.15 ml for men and 0.11 +/- 0.10 ml for women. The volume of stimulated saliva was 4.99 +/- 2.67 ml for men and 3.67 +/- 2.25 ml for women. The percentage of subjects taking medication was 64.7% (238/368). Mean number of medications was 2.08 +/- 2.26, with no significant difference with gender (2.01 +/- 2.37 for men, 2.16 +/- 2.16 for women). In a stepwise multiple regression analysis with volume of saliva as the objective variable and number of drugs by category as explanatory variables, significant explanatory variables in addition to gender and number of medications were blood-coagulating agents, Ca antagonists and peptic ulcer drugs for volume of unstimulated saliva, and diabetes medications and peptic ulcer drugs for volume of stimulated saliva.Conclusion:These findings suggest that differences exist between gender in volume of saliva for elderly individuals, and that the volume of saliva is affected by the number and type of medications.