Probing rat brain oxygenation with near-infrared spectroscopy (NIRS) and magnetic resonance imaging (MRI).
Probing rat brain oxygenation with near-infrared spectroscopy (NIRS) and magnetic resonance imaging (MRI).
复制标题
使用近红外光谱 (NIRS) 和磁共振成像 (MRI) 探测大鼠脑氧合。
DOI：
10.1007/978-1-4615-0205-0_33
复制
发表时间：
2003
影响因子：
--
通讯作者：
Chance,Britton
中科院分区：
文献类型：
--
作者：
Chen,Yu;Intes,Xavier;Tailor,DharmeshR;Regatte,RavinderR;Ma,HongYan;Ntziachristos,Vasilis;Leigh,JohnS;Reddy,Ravinder;Chance,Britton
Near-infrared spectroscopy (NIRS) has been a promising technique for non-invasively quantifying tissue chromophores concentrations. One of the potential applications is the monitoring of cerebral blood volume and blood oxygenation saturation. Theories and instruments have been developed to improve the measurement sensitivity and accuracy“.In vivostudies have been performed with calibration of NIRS saturation using the weighted average of global arterial and venous saturations. Comparison of NIRS results with other non-invasive imaging modalities such as MRI can provide more information on the co-localized region, and has attracted a lot of interest recently. Several studies have reported the temporal correlation between the fMRI BOLD (blood oxygenation level dependent) signal and deoxy-hemoglobin concentration measured by NIRS. To our knowledge, the quantitative relation has not been reported. In this study, we show the correlation of deoxy-hemoglobin concentration as well as oxygen saturation measured with NIRS and the conventional T2*-weighted BOLD MM signal for anin vivorat model during inhalation of gas with different concentrations of oxygen (FiO2).
