Nor-triterpenoids from the fruiting bodies of Ganoderma lucidum and their inhibitory activity against FAAH
Nor-triterpenoids from the fruiting bodies of Ganoderma lucidum and their inhibitory activity against FAAH
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DOI：
10.1080/14786419.2022.2078817
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发表时间：
2022-05-17
影响因子：
2.2
通讯作者：
Wang, Ruoyu
中科院分区：
文献类型：
--
作者：
Li, Dawei;Leng, Yueqi;Wang, Ruoyu
从灵芝子实体中分离得到两个新的非三萜类化合物灵芝酚A(1)、B(2)和一个新的天然产物灵芝酚C(3)，以及三个已知的非三萜类化合物（4-6）。这些分离物的化学结构通过一维和二维核磁共振、hresms和x射线晶体学分析进行了确定。体外实验考察了分离的三萜（1-6）对FAAH的抑制作用，化合物4的抑制率为70.27%。此外，对化合物（1-6）对LOVO、MCF-7和RAW264.7细胞的细胞毒作用进行了评估，发现它们没有明显的细胞毒性。
Two new nor-triterpenoids ganodrenol A (1), B (2), and a new natural product ganodrenol C (3), along with three known nor-triterpenoids (4-6) were isolated from the fruiting bodies of Ganoderma lucidum. The chemical structures of these isolates were determined by 1 D and 2 D NMR, HRESIMS, and X-ray crystallography analysis. The inhibitory effects of isolated triterpenoids (1-6) against FAAH were evaluated by an in vitro assay, and compound 4 showed an inhibition rate of 70.27%. In addition, the cytotoxic effect of compounds (1-6) was evaluated against LOVO, MCF-7, and RAW264.7 cells, which displayed no significant cytotoxicity.