Alpha-Tocopherol Transfer Protein (alpha-TTP): Insights from Alpha-Tocopherol Transfer Protein Knockout Mice.
Alpha-Tocopherol Transfer Protein (alpha-TTP): Insights from Alpha-Tocopherol Transfer Protein Knockout Mice.
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DOI：
10.4162/nrp.2007.1.4.247
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发表时间：
2007-01-01
影响因子：
2.4
通讯作者：
Traber, Maret G
中科院分区：
文献类型：
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作者：
Lim, Yunsook;Traber, Maret G
α-生育酚转移蛋白（α-TTP）是一种肝细胞溶质转运蛋白，可促进α-生育酚（α-T）转移到肝分泌的血浆脂蛋白中。α-TTP的遗传缺陷，如膳食维生素E缺乏症，与不孕症，肌肉无力和神经系统疾病有关。人类和α-TTP缺陷（α-TTP（-/-））小鼠表现出严重的血浆和组织维生素E缺乏症，可以通过足够的饮食α-T补充来减轻。本文综述了近年来关于利用α-TTP（-/-）小鼠进行研究的文献。α-TTP（-/-）小鼠体内的维生素E水平似乎与饮食中α-T的量或组织中α-TTP蛋白的水平没有直接关系。α-TTP（-/-）小鼠似乎是研究α-T在组织维生素E代谢中的特定作用的良好模型。此外，alpha-TTP（-/-）小鼠似乎可用于阐明alpha-TTP除了将alpha-T从肝脏转移到血浆脂蛋白组分的公认功能之外的功能。
Alpha-tocopherol transfer protein (alpha-TTP) is a liver cytosolic transport protein that faciliates alpha-tocopherol (alpha-T) transfer into liver secreted plasma lipoproteins. Genetic defects in alpha-TTP, like dietary vitamin E deficiency, are associated with infertility, muscular weakness and neurological disorders. Both human and alpha-TTP deficient (alpha-TTP(-/-)) mice exhibit severe plasma and tissue vitamin E deficiency that can be attenuated by sufficient dietary alpha-T supplementations. In this review, we summarize the literature concerning studies utilizing the alpha-TTP(-/-) mice. Levels of vitamin E in the alpha-TTP(-/-) mice do not appear to be directly related to the amounts of dietary alpha-T or to the levels of alpha-TTP protein in tissues. The alpha-TTP(-/-) mice appear to present a good model for investigating the specific role of alpha-T in tissue vitamin E metabolism. Furthermore, alpha-TTP(-/-) mice appear to be useful to elucidate functions of alpha-TTP beyond its well recognized functions of transferring alpha-T from liver to plasma lipoprotein fractions.