Prevalence of psychiatric disorders in 4 to 16-year-olds with Williams syndrome
Prevalence of psychiatric disorders in 4 to 16-year-olds with Williams syndrome
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DOI：
10.1002/ajmg.b.30344
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发表时间：
2006-09-05
影响因子：
2.8
通讯作者：
Mervis, Carolyn B.
中科院分区：
文献类型：
--
作者：
Leyfer, Ovsanna T.;Woodruff-Borden, Janet;Mervis, Carolyn B.
对119例4-16岁威廉姆斯综合征（WS）儿童的一系列精神疾病的患病率进行了评估。大多数儿童（80.7%）符合至少一个DSM-IV诊断标准。最常见的诊断是注意力缺陷多动障碍（ADHD; 64.7%）和特定恐惧症（53.8%）。ADHD的主要类型作为CA的函数有显著的变化，从最年轻组（4-6岁）的合并到最年长组（11-16岁）的疏忽。广泛性焦虑障碍（GAD）的患病率随年龄增长而显著增加。这些发现是朝着定义WS的行为表型迈出的又一步。
The prevalence of a range of DSM-IV psychiatric disorders in a sample of 119 4-16-year-old children with Williams syndrome (WS) was assessed using a structured diagnostic interview with their parents. Most children (80.7%) met criteria for at least one DSM-IV diagnosis. The most prevalent diagnoses were Attention Deficit/Hyperactivity Disorder (ADHD; 64.7%) and Specific Phobia (53.8%). There was a significant shift in Predominant Type of ADHD as a function of CA, from Combined for the youngest group (ages 4-6 years) to Inattentive for the oldest group (ages 11-16 years). The prevalence of Generalized Anxiety Disorder (GAD) increased significantly with age. These findings are another step toward defining the behavioral phenotype of WS. (c) 2006 Wiley-Liss, Inc.