Alcohol and fat promote steatohepatitis: a critical role for fat-specific protein 27/CIDEC.
Alcohol and fat promote steatohepatitis: a critical role for fat-specific protein 27/CIDEC.
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DOI：
10.1136/jim-2016-000204
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发表时间：
2016-08
期刊：
影响因子：
--
通讯作者：
Gao B
中科院分区：
文献类型：
--
作者：
Liangpunsakul S;Gao B
酒精性肝病（ALD）是全球范围内的一个主要公共卫生问题，是终末期肝病的主要原因。虽然最终控制ALD需要预防酒精滥用，但更好地了解酒精诱导的肝损伤机制可能会导致脂肪肝，酒精性肝炎的治疗，以及预防或延迟肝硬化的发生。ALD发病机制中几个新概念的阐明和发现提高了我们对复杂机制的理解，并有可能开发新的治疗策略。本文就脂肪特异性蛋白27/CIDEC在ALD发病机制中的作用，提供了最新的分子机制研究进展。
Alcoholic liver disease (ALD) is a major public health problem worldwide and is the leading cause of end-stage liver disease. While the ultimate control of ALD will require the prevention of alcohol abuse, better understanding of the mechanisms of alcohol-induced liver injury may lead to treatments of fatty liver, alcoholic hepatitis, and prevention or delay of occurrence of cirrhosis. The elucidation and the discovery of several new concepts in ALD pathogenesis have raised our understanding on the complex mechanisms and the potential in developing the new strategies for therapeutic benefits. In this review, we provide the most up-to-date information on the basic molecular mechanisms focusing on the role of fat-specific protein 27/CIDEC in the pathogenesis of ALD.