PRIMARY HERPES-SIMPLEX VIRUS (TYPE-1) INFECTION DELAYS HEALING OF ORAL EXCISIONAL AND EXTRACTION WOUNDS IN THE RAT
PRIMARY HERPES-SIMPLEX VIRUS (TYPE-1) INFECTION DELAYS HEALING OF ORAL EXCISIONAL AND EXTRACTION WOUNDS IN THE RAT
复制标题
DOI：
10.1111/j.1600-0714.1990.tb00789.x
复制
发表时间：
1990-11-01
影响因子：
3.3
通讯作者：
HIRSCH, JM
中科院分区：
文献类型：
--
作者：
HEDNER, E;VAHLNE, A;HIRSCH, JM
研究急性单纯疱疹病毒1型（HSV-1）感染对大鼠口腔内伤口和拔牙槽愈合过程的影响。 切除标准尺寸的颊粘膜，拔出臼齿，并局部应用 HSV-1 悬浮液。 病毒感染伤口的临床特征为红斑和肿胀，组织学特征为第一周内大量炎症细胞浸润和脓肿。 研究发现，急性 HSV-1 感染会显着延迟两种类型伤口的愈合 3 天。 阿昔洛韦 (ACV) 抗病毒治疗可降低炎症程度并改善感染伤口的愈合。 目前的结果表明，在 HSV-1 存在的情况下，口腔伤口的愈合会延迟且受到干扰。 这些发现与口腔手术干预相结合，对于原发性或潜伏性 HSV-1 感染可能具有临床意义。
The effect of acute herpes simplex virus type 1 (HSV-1) infection on the healing process of intraoral wounds and tooth extraction sockets in the rat was studied. A standardized size of the buccal mucosa was excised and molars were extracted and a HSV-1 suspension was topically applied. The virus infected wounds were clinically characterized by erythema and swelling and histologically by heavy inflammation cell infiltrate and abscesses during the first week. The acute HSV-1 infection was found to significantly delay healing of both types of wounds by 3 days. Antiviral treatment with acyclovir (ACV) decreased the degree of inflammation and improved healing of the infected wounds. The present results indicate a delayed and disturbed healing of wounds in the oral cavity in the presence of HSV-1. The findings may have a clinical significance for primary or latent HSV-1 infections in conjunction with surgical intervention in the oral cavity.