Using the Wash U Epigenome Browser to examine genome-wide sequencing data.
Using the Wash U Epigenome Browser to examine genome-wide sequencing data.
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DOI：
10.1002/0471250953.bi1010s40
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发表时间：
2012-12
影响因子：
--
通讯作者：
Wang, Ting
中科院分区：
文献类型：
--
作者：
Zhou, Xin;Wang, Ting
本单元介绍了 Wash U Epigenome 浏览器，这是一种下一代基因组数据可视化系统。该浏览器目前托管人类和模型生物体的 ENCODE 和路线图表观基因组学数据。浏览器显示整个或部分基因组、特定基因集或途径及其元数据上下文中的许多基于测序的数据集。研究人员可以根据给定的特征集（包括元数据特征、注释的生物途径以及用户定义的基因或基因组坐标集合）以交互方式排序、过滤、聚合、分类和显示数据。此外，可以对选定的数据进行统计测试。各个实验室可以将其测序或基于阵列的数据作为自定义轨迹上传，并在联盟数据的背景下显示它们，以便进行直接比较。浏览器是一种日益重要且广泛使用的工具，用于从前所未有的大量高质量基因组、表观基因组和表达数据中获取生物学见解。
This unit describes the Wash U Epigenome Browser, a next-generation genomic data visualization system. The Browser currently hosts ENCODE and Roadmap Epigenomics data for human and model organisms. The Browser displays many sequencing-based data sets across all or part of the genome, on specific gene sets or pathways, and in the context of their metadata. Investigators can order, filter, aggregate, classify and display data interactively based on given feature sets including metadata features, annotated biological pathways, and user-defined collections of genes or genomic coordinates. Further, statistical tests can be performed on selected data. Individual labs can upload their sequencing or array-based data as custom tracks and display them in the context of consortium data, allowing for direct comparisons. The Browser is an increasingly important and widely accessible tool for deriving biological insights from unprecedented amounts of high-quality genomic, epigenomic and expression data.