Detection of Early Cancer: Genetics or Immunology? Serum Autoantibody Profiles as Markers of Malignancy
Detection of Early Cancer: Genetics or Immunology? Serum Autoantibody Profiles as Markers of Malignancy
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DOI：
10.2174/1871520615666150716105255
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发表时间：
2015-01-01
影响因子：
2.8
通讯作者：
Sviridov, Pavel
中科院分区：
文献类型：
--
作者：
Poletaev, Alexander;Pukhalenko, Alexander;Sviridov, Pavel
寻找在非常早期阶段检测癌症的有效方法是目前癌症研究的重中之重。虽然已经在人类癌症中鉴定出许多致癌基因并与之相关，但过去50年的分子和遗传学研究并未在癌症的诊断或治疗方面取得突破。因此，癌基因在致癌作用中的作用仍然不清楚，它们在人类癌症诊断中的有用性也不清楚。本文就癌基因的概念和基于抗体芯片的癌症早期检测方法进行了综述。
The search for effective methods for detecting cancers at very early stages is currently a top priority of cancer research. While numerous oncogenes have been identified in and associated with human cancers, the last 50 years of molecular and genetic studies have not led to a breakthrough in either the diagnosis or the treatment of cancers. Therefore, the role of oncogenes in carcinogenesis is still unclear, as is their usefulness in the diagnosis of human cancers. In the present review, we discuss the concept of oncogenes and summarize the current approaches for the early detection of human cancers based on antibodies arrays.