Equine Allogeneic Chondrogenic Induced Mesenchymal Stem Cells Are an Effective Treatment for Degenerative Joint Disease in Horses
Equine Allogeneic Chondrogenic Induced Mesenchymal Stem Cells Are an Effective Treatment for Degenerative Joint Disease in Horses
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DOI：
10.1089/scd.2018.0061
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发表时间：
2019-03-01
影响因子：
4
通讯作者：
Spaas, Jan H.
中科院分区：
文献类型：
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作者：
Broeckx, Sarah Y.;Seys, Bert;Spaas, Jan H.
退行性关节疾病是马从娱乐骑马或表演生涯中提前退休的主要原因之一。该疾病最初由正常软骨的异常负荷或异常软骨的正常负荷触发。这种原发性损伤伴随着关节炎症，这导致关节软骨的进一步进行性退化和周围组织的变化。因此，为了寻找有效的治疗方法，75匹具有退化性球节关节疾病早期体征的成年马入组了一项随机、多中心、双盲和安慰剂对照研究。50只动物关节内注射由同种异体软骨诱导间充质干细胞（ciMSC）和马同种异体血浆组成的试验用兽药产品（IVP），25匹马注射0.9% NaCl（生理盐水）对照产品。治疗后3 ~ 18周，跛行评分（P
Degenerative joint disease is one of the main causes of equine early retirement from pleasure riding or a performance career. The disease is initially triggered by an abnormal loading of normal cartilage or a normal loading of abnormal cartilage. This primary insult is accompanied with joint inflammation, which leads to further progressive degeneration of the articular cartilage and changes in the surrounding tissues. Therefore, in search for an effective treatment, 75 adult horses with early signs of degenerative fetlock joint disease were enrolled in a randomized, multicenter, double-blinded, and placebo-controlled study. Fifty animals were injected intra-articularly with the investigational veterinary product (IVP) consisting of allogeneic chondrogenic induced mesenchymal stem cells (ciMSCs) with equine allogeneic plasma, and 25 horses were injected with 0.9% NaCl (saline) control product. From week 3 to 18 after treatment, lameness scores (P