Regulation of the Na+-Cl- cotransporter by dietary NaCl: a role for WNKs, SPAK, OSR1, and aldosterone.
Regulation of the Na+-Cl- cotransporter by dietary NaCl: a role for WNKs, SPAK, OSR1, and aldosterone.
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DOI:
10.1038/ki.2008.477
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发表时间:
2008-12
影响因子:
19.6
通讯作者:
Vallon V
中科院分区:
文献类型:
--
作者:
Vallon V
This commentary aims to integrate or interrelate the available data with the current study by Chiga and coworkers, which defines an important influence of aldosterone in the phosphorylation and thus activation of NCC in response to changes in NaCl intake, and implicates the involvement of SPAK/OSR1 kinases and WNKs.
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