Short telomere length and breast cancer risk: A study in sister sets
Short telomere length and breast cancer risk: A study in sister sets
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DOI：
10.1158/0008-5472.can-06-3490
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发表时间：
2007-06-01
期刊：
影响因子：
11.2
通讯作者：
Santella, Regina M.
中科院分区：
文献类型：
--
作者：
Shen, Jing;Terry, Mary Beth;Santella, Regina M.
端粒由位于染色体末端的TTAGGG序列的串联重复序列组成，在维持染色体稳定性方面起关键作用。先前的研究表明，短端粒与人类膀胱癌、头颈癌、肺癌和肾细胞癌的风险增加有关。我们调查了268个家庭（287个乳腺癌病例和350个姐妹对照）中白色血细胞端粒长度与乳腺癌风险之间的关系。通过定量PCR评估端粒长度。病例组的平均端粒长度（平均值0.70;范围0.03-1.95）短于未受影响的对照姐妹篇（平均值0.74;范围0.03-2.29），但未观察到显著差异（P = 0.11）。当受试者根据对照组的端粒长度中位数（0.70）进行分类时，在调整献血时的年龄和吸烟状况后，受影响的姐妹篇与未受影响的姐妹篇相比端粒较短[比值比（OR），1.3; 95%置信区间（95%CI），0.9-1.8]，但这种关联没有统计学意义。端粒长度四分位数（Q4最短与Q1最长）的相关性也支持端粒长度较短的风险增加，尽管该相关性没有统计学意义（OR，1.6; 95%CI，0.9-2.7）。与绝经后女性（Q4 vs Q1的OR，1.3; 95% CI，0.5-3.6）相比，绝经前女性（OR，2.1; 95% CI，0.8-5.5）中的这种相关性更明显。如果这些相关性在更大规模的研究中得到重复，它们提供了适度的流行病学证据，即端粒长度缩短可能与乳腺癌风险相关。
Telomeres consist of a tandem repeats of the sequence TTAGGG at the ends of chromosomes and play a key role in the maintenance of chromosomal stability. Previous studies indicated that short telomeres are associated with increased risk for human bladder, head and neck, lung, and renal cell cancer. We investigated the association between white blood cell telomere length and breast cancer risk among 268 family sets (287 breast cancer cases and 350 sister controls). Telomere length was assessed by quantitative PCR. The mean telomere length was shorter in cases (mean, 0.70; range, 0.03-1.95) than in unaffected control sisters (mean, 0.74; range, 0.03-2.29), but no significant difference was observed (P = 0.11). When subjects were categorized according to the median telomere length in controls (0.70), affected sisters had shorter telomeres compared with unaffected sisters after adjusting for age at blood donation and smoking status [odds ratio (OR), 1.3; 95% confidence interval (95% CI), 0.9-1.8], but the association was not statistically significant. The association by quartile of telomere length (Q4 shortest versus Q1 longest) also supported an increase in risk from shorter telomere length, although the association was not statistically significant (OR, 1.6; 95% Cl, 0.9-2.7). This association was more pronounced among premenopausal women (OR, 2.1; 95% Cl, 0.8-5.5) than postmenopausal women (OR, 1.3; 95% Cl, 0.5-3.6 for Q4 versus Q1). If these associations are replicated in larger studies, they provide modest epidentiologic evidence that shortened telomere length may be associated with breast cancer risk.