An active zymogen: unravelling the mystery of tissue-type plasminogen activator.
An active zymogen: unravelling the mystery of tissue-type plasminogen activator.
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活性酶原：揭开组织型纤溶酶原激活剂的神秘面纱。
作者：
M. Stubbs;M. Renatus;W. Bode
In contrast to almost all other proteinases, human tissue-type plasminogen activator (tPA) is also proteolytically active in its zymogen or single-chain form. The closely related plasminogen activator isolated from vampire bat saliva (vPA) acts exclusively in the single-chain form, lacking the requisite cleavage site for proteolytic activation. Recent structural studies on the proteolytic domains of vPA and human tPA in two- and single-chain forms reveal the mechanism of this anomalous activity. The PA-catalyzed proteolytic conversion of plasminogen to plasmin, responsible for the initiation of fibrinolysis, is fibrin-dependent; comparative structural analysis of the plasminogen activators provides clues as to the role of fibrin as cofactor.
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DOI：
10.1073/pnas.88.17.7481
发表时间：
1991-09-01
影响因子：
11.1
作者：
JONES, JI;DERCOLE, AJ;CLEMMONS, DR
通讯作者：
CLEMMONS, DR
单链和双链组织纤溶酶原激活剂 (t-PA) 之间的构象相似性：对单链 t-PA 激活机制的影响。
影响因子：
2.9
作者：
Nienaber,VL;Young,SL;Birktoft,JJ;Higgins,DL;Berliner,LJ
通讯作者：
Berliner,LJ
DOI：
10.1073/pnas.87.9.3542
发表时间：
1990-05-01
影响因子：
11.1
作者：
SZALA, S;FROEHLICH, M;LINNENBACH, AJ
通讯作者：
LINNENBACH, AJ
影响因子：
4.1
作者：
BUCK, MR;KARUSTIS, DG;SLOANE, BF
通讯作者：
SLOANE, BF
影响因子：
3.5
作者：
CAO, LQ;TAGGART, RT;SLOANE, BF
通讯作者：
SLOANE, BF