Assessment of a genetic contribution to osteoarthritis of the hip: sibling study
Assessment of a genetic contribution to osteoarthritis of the hip: sibling study
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DOI：
10.1136/bmj.321.7270.1179
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发表时间：
2000-11-11
影响因子：
--
通讯作者：
Doherty, M
中科院分区：
文献类型：
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作者：
Lanyon, P;Muir, K;Doherty, M
目的通过x线平片结构变化，探讨遗传因素对髋关节骨关节炎发生发展的影响。设计同胞研究。背景：英格兰诺丁汉郡。研究对象392名患有严重程度足以需要全髋关节置换术的髋关节骨性关节炎，604名研究对象的兄弟姐妹，1718名接受静脉尿路造影的研究对象。主要结局指标：兄弟姐妹髋关节骨关节炎的优势比。结果经年龄调整后的兄弟姐妹中，可能患有髋关节骨关节炎的比值比为4.9(95%可信区间，3.9 ~ 6.4)，确定患有髋关节骨关节炎的比值比为6.4（4.5 ~ 9.1）。通过调整其他危险因素，这些值没有显著改变。结论从x线平片结构变化可以看出，兄弟姐妹患髋关节骨关节炎的风险较高。一种解释是髋关节骨关节炎受到强烈的遗传影响。
Objectives To study the influence of genetics on the development of hip osteoarthritis as determined by structural change on plain radiographs.Design Sibling study.Setting Nottinghamshire, England.Participants 392 index participants with hip osteoarthritis of sufficient severity to warrant total hip replacement, 604 siblings of the index participants, and 1718 participants who had undergone intravenous urography.Main outcome measure Odds ratios for hip osteoarthritis in siblings.Results The age adjusted odds ratios in siblings were 4.9 (95% confidence interval, 3.9 to 6.4) for probable hip osteoarthritis and 6.4 (4.5 to 9.1) for definite hip osteoarthritis. These values were not significantly altered by adjusting for other risk factors.Conclusion Siblings have a high risk of hip osteoarthritis as shown by structural changes on plain radiographs. One explanation is that hip osteoarthritis is under strong genetic influence.