Botanicals and the metabolic syndrome
Botanicals and the metabolic syndrome
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DOI：
10.1093/ajcn/87.2.481s
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发表时间：
2008-02-01
影响因子：
7.1
通讯作者：
Lefevre, Michael
中科院分区：
文献类型：
--
作者：
Cefalu, William T.;Ye, Jianping;Lefevre, Michael
代谢综合征描述的人类疾病的特征是，除了非传统的心血管疾病风险因素（如炎症过程和凝血系统异常）外，还存在心血管疾病的传统风险因素（如高血压、血脂异常、葡萄糖耐受不良和肥胖）。虽然代谢综合征的具体病因尚不清楚，但胰岛素抵抗（胰岛素浓度正常或升高反映生物反应受损的临床状态）是存在的，被认为是一种关键的病理生理异常。因此，代谢综合征可以被认为是一种前驱糖尿病状态，并极大地增加了人类的发病率和死亡率。鉴于代谢综合征的公共卫生意义，迫切需要成功的策略来干预其发展。因此，有效解决致病机制的植物性营养补充剂，结合公众对植物性补充剂的接受和广泛使用，代表了一种有吸引力的，新颖的和潜在有效的解决问题的方法。因此，我们植物研究中心的总体目标是全面评估植物药在解决导致胰岛素抵抗和代谢综合征发展的病理生理机制。目前，3个研究项目中的每一个都评估了一种特定的植物[俄罗斯龙蒿（Artemisia dracunculus L），石莲花（Sinocrassula indica）和葡萄（Vitus vinifera）花青素]，并评估了对导致胰岛素抵抗发展的致病机制的影响。随着我们研究的完成，我们预计将更好地了解胰岛素抵抗发展的细胞机制以及植物药在调节代谢综合征进展中的作用。
Metabolic syndrome describes the human condition characterized by the presence of coexisting traditional risk factors for cardiovascular disease, such as hypertension, dyslipidemia, glucose intolerance, and obesity, in addition to nontraditional cardiovascular disease risk factors, such as inflammatory processes and abnormalities of the blood coagulation system. Although the specific etiology for metabolic syndrome is not known, insulin resistance-a clinical state in which a normal or elevated insulin concentration reflects an impaired biological response-is present and is considered a key pathophysiologic abnormality. As such, metabolic syndrome can be considered to be a prediabetic state and contributes greatly to increased morbidity and mortality in humans. Given the public health significance of metabolic syndrome, successful strategies are direly needed to intervene in its development. As such, nutritional supplementation with botanicals that effectively address pathogenic mechanisms, combined with the acceptance and widespread use of botanical supplements by the general public, represents an attractive, novel, and potentially effective approach to the problem. Thus, the overall goal of our botanical research center is to comprehensively evaluate botanicals in addressing the pathophysiologic mechanisms that lead to the development of insulin resistance and metabolic syndrome. Currently, each of the 3 research projects evaluates a specific botanical [Russian tarragon (Artemisia dracunculus L), shilianhua (Sinocrassula indica), and grape (Vitus vinifera) anthocyanins] and assesses the effect on pathogenic mechanisms leading to the development of insulin resistance. With the completion of our research, we anticipate a better understanding of the cellular mechanisms by which insulin resistance develops and the role of botanicals in modulating the progression to metabolic syndrome.