A DOUBLE-BLIND-STUDY OF THE EFFECTIVENESS OF A HIGH-EFFICIENCY PARTICULATE AIR (HEPA) FILTER IN THE TREATMENT OF PATIENTS WITH PERENNIAL ALLERGIC RHINITIS AND ASTHMA
A DOUBLE-BLIND-STUDY OF THE EFFECTIVENESS OF A HIGH-EFFICIENCY PARTICULATE AIR (HEPA) FILTER IN THE TREATMENT OF PATIENTS WITH PERENNIAL ALLERGIC RHINITIS AND ASTHMA
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DOI：
10.1016/0091-6749(90)90050-e
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发表时间：
1990-06-01
影响因子：
14.2
通讯作者：
DEMASI, JM
中科院分区：
文献类型：
--
作者：
REISMAN, RE;MAURIELLO, PM;DEMASI, JM
本研究旨在评估高效微粒空气（HEPA）过滤器缓解过敏性呼吸道症状的有效性。32例患者在秋季和冬季有症状的常年性鼻炎和/或哮喘，并有阳性的皮肤试验与屋尘或屋尘螨提取物。在卧室中放置一台RACAIRE室内空气净化器8周。以随机方式，使用活性过滤器4周，使用空白过滤器4周。颗粒物平均减少70%。0.3使用HEPA过滤器时，在双盲设计中，通过分析患者的症状/药物评分和主观评价来评估结果。对于整个研究，安慰剂和活性滤器治疗期间的总症状/药物评分或个体症状评分无差异。对无呼吸道感染的每个滤器周期的最后2周进行的分析表明，总体和个体症状存在明确差异，表明有源滤器获益。患者的主观反应也表明从过滤器中受益。总体印象是HEPA过滤器可以减少过敏性呼吸道症状。
This study was designed to assess the effectiveness of a high-efficiency particulate air (HEPA) filter in alelviating allergic respiratory symptoms. Thirty-two patients were studied who had symptomatic perennial rhinitis and/or asthma during the fall and winter months and had a positive skin test with house dust or house dust-mite extract. An ENVIRACAIRE room air cleaner was placed in the bedroom for 8 weeks. In a random manner, the active filter was used for 4 weeks and a blank filter for 4 weeks. There was an average 70% reduction in the particulate matter .gtoreq. 0.3 .mu.m with the HEPA filter. In a double-blind design, results were assessed by analysis of the patients'' symptom/medication scores and subjective evaluation. For the total study, there was no difference in the total symptom/medication scores or individual symptom scores during the placebo and active-filter periods. Analysis of the last 2 weeks of each filter period in which respiratory infection was absent demonstrated definite differences in total and individual symptoms, suggesting active-filter benefit. Patients'' subjective responses also suggested benefit from the filter. The overall impression is that the HEPA filter can reduce allergic respiratory symptoms.