Advances in drug delivery and medical imaging using colloidal lyotropic liquid crystalline dispersions
Advances in drug delivery and medical imaging using colloidal lyotropic liquid crystalline dispersions
复制标题
DOI：
10.1016/j.jcis.2012.10.014
复制
发表时间：
2013-03-01
影响因子：
9.9
通讯作者：
Drummond, Calum J.
中科院分区：
文献类型：
--
作者：
Mulet, Xavier;Boyd, Ben J.;Drummond, Calum J.
这篇专题文章的首要目标是回顾药物输送领域的最新进展，特别是涉及胶体溶致液晶分散体。用于药物递送应用的先进颗粒的开发被认为是纳米医学进步的下一个必要步骤。概述了自组装纳米粒子的制备方法及其在药物释放和医学成像中的应用。通过调节小分子两亲物的自组装特性来控制粒子内部结构的基本概念。治疗诊断学是这类胶体材料的一个令人兴奋的新兴领域，并描述了可以掺入的治疗化合物和医学成像剂的类型以及它们的制备方法。还讨论了胶体分散体的稳定性和生物相容性。最后概述了病变特异性主动和被动靶向。利用这样一个多功能的药物输送平台不仅是必不可少的下一代生物活性分子的交付，而且在创造新的诊断工具。皇冠版权所有（C）2012由Elsevier Inc.发布。All rights reserved.
The overarching goal of this feature article is to review the recent developments in the field of drug delivery specifically involving colloidal lyotropic liquid crystalline dispersions. The development of advanced particles for drug delivery applications is regarded as the next necessary step in the advancement of nanomedicine. An outline of the state of the art in preparation and application of self-assembled nanoparticles to drug delivery and medical imaging is presented. The basic concepts for controlling the nature of the internal structure of particles by tuning the self-assembly properties of small molecule amphiphiles is covered. Theranostics is an exciting emerging area for this colloidal material class, and the types of therapeutic compounds and medical imaging agents that can be incorporated as well as their methods of preparation are described. The stabilisation and biocompatibility of the colloidal dispersions are also discussed. Finally an overview of lesion-specific active and passive targeting is presented. Exploiting such a multi-functional drug delivery platform is essential to not only the next generation delivery of bioactive molecules but also in the creation of new diagnostic tools. Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved.