EEG Spectral Analysis in Primary Insomnia: NREM Period Effects and Sex Differences
EEG Spectral Analysis in Primary Insomnia: NREM Period Effects and Sex Differences
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DOI：
10.1093/sleep/31.12.1673
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发表时间：
2008-12-01
期刊：
影响因子：
5.6
通讯作者：
Kupfer, David J.
中科院分区：
文献类型：
--
作者：
Buysse, Daniel J.;Germain, Anne;Kupfer, David J.
研究目的：比较原发性失眠症（PI）和睡眠良好者对照组（GSC）的NREM脑电功率，检查性别和NREM期的影响;检查脑电功率、临床特征和自我睡眠报告之间的关系。设计：过夜多导睡眠图研究。设置：睡眠实验室。参与者：PI（n = 48; 29名女性）和GSC（n = 25; 15名女性）。干预：无。测量：计算1-50 Hz的EEG功率，用于跨越四个NREM时期的无伪影睡眠时期。重复测量混合效应模型对比组间差异，EEG频带，NREM期。EEG功率-频率曲线进行了建模使用回归固定结spline.Results：混合模型显示没有显着的组（PI与GSC）的差异;边缘性别差异（δ和θ波段）; NREM期间的显着差异;和组 * 性别和组 *NREM期间的相互作用，特别是在β和γ波段。模拟功率-频率曲线显示，在整个夜间NREM没有组间差异，但PI有较高的功率比GSC从18-40 Hz的第一NREM期间。在女性中，PI在前3个NREM时期的16至44 Hz功率高于GSC，在所有NREM时期的3至5 Hz功率均高于GSC。PI和GSC男性在EEG功率方面没有一致的差异。高频EEG功率与PI的临床或主观睡眠评级无关。结论：PI的女性，但不是男性，在NREM睡眠期间与GSC相比，高频和低频EEG活动增加，特别是在NREM早期。性别和NREM期可能会缓和PI和GSC之间的定量EEG差异。
Study Objectives: To compare NREM EEG power in primary insomnia (PI) and good sleeper controls (GSC), examining both sex and NREM period effects; to examine relationships between EEG power, clinical characteristics, and self-reports of sleep.Design: Overnight polysomnographic study.Setting: Sleep laboratory.Participants: PI (n = 48; 29 women) and GSC (n = 25; 15 women).Interventions: None.Measurements: EEG power from 1-50 Hz was computed for artifact-free sleep epochs across four NREM periods. Repeated measures mixed effect models contrasted differences between groups, EEG frequency bands, and NREM periods. EEG power-frequency curves were modeled using regressions with fixed knot splines.Results: Mixed models showed no significant group (PI vs. GSC) differences; marginal sex differences (delta and theta bands); significant differences across NREM periods; and group*sex and group*NREM period interactions, particularly in beta and gamma bands. Modeled power-frequency curves showed no group difference in whole-night NREM, but PI had higher power than GSC from 18-40 Hz in the first NREM period. Among women, PI had higher 16 to 44-Hz power than GSC in the first 3 NREM periods, and higher 3 to 5-Hz power across all NREM periods. PI and GSC men showed no consistent differences in EEG power. High-frequency EEG power was not related to clinical or subjective sleep ratings in PI.Conclusions: Women with PI, but not men, showed increased high-frequency and low-frequency EEG activity during NREM sleep compared to GSC, particularly in early NREM periods. Sex and NREM period may moderate quantitative EEG differences between PI and GSC.