The Biological Basis of Diffusion Anisotropy
The Biological Basis of Diffusion Anisotropy
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DOI：
10.1016/b978-0-12-374709-9.00006-7
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发表时间：
2009-01-01
期刊：
影响因子：
--
通讯作者：
Beaulieu, Christian
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文献类型：
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作者：
Beaulieu, Christian
水在神经纤维、脊髓白质或脑白质等神经纤维中的各向异性扩散是利用弥散张量成像（diffusion tensor imaging， DTI）追踪纤维通路的基础。事实上，水的扩散对潜在的组织微观结构很敏感，这为测量这些神经纤维的方向和完整性提供了一种独特的方法，这可能有助于评估许多神经系统疾病。本章的目的是表征水扩散的核磁共振测量及其各向异性（即方向依赖）与神经纤维底层微观结构的关系。重点将放在体外和体内的神经系统模型上
Anisotropic water diffusion in neural fibers such as nerve, white matter in spinal cord, or white matter in brain forms the basis for the utilization of diffusion tensor imaging (DTI) to track fiber pathways. The fact that water diffusion is sensitive to the underlying tissue microstructure provides a unique method of measuring the orientation and integrity of these neural fibers which may be useful in assessing a number of neurological disorders. The purpose of this chapter is to characterize the relationship of nuclear magnetic resonance measurements of water diffusion and its anisotropy (i.e. directional dependence) with the underlying microstructure of neural fibers. The emphasis will be on model neurological systems both in vitro and in vivo