Morphology of nasal-cavity tumours in rats after chronic inhalation of 1,2-dibromo-3-chloropropane.
Morphology of nasal-cavity tumours in rats after chronic inhalation of 1,2-dibromo-3-chloropropane.
复制标题
慢性吸入1,2-二溴-3-氯丙烷后大鼠鼻腔肿瘤的形态学。
作者：
G. Reznik;H. Reznik;J. Ward;S. Stinson
每组50只F344大鼠，雌雄同体，吸入浓度为0.6或3.0 pts/10(6)的1,2-二溴-3-氯丙烷（DBCP），每天6小时，每周5天，持续103周。男女各50只吸入过滤空气的大鼠作为未暴露的对照组。所有幸存者在104周时死亡。高达93%的雄性和雌性大鼠发生鼻腔肿瘤。大多数肿瘤为腺瘤、鳞状细胞乳头状瘤、鳞状细胞癌和腺癌。在低剂量组中，78%的男性和66%的女性肿瘤是良性的，而在高剂量组中，89%的男性和76%的女性肿瘤是恶性的。73%的男性和51%的女性发现癌通过筛状板侵入大脑或转移到区域淋巴结。电镜检查提示嗅上皮基底细胞是低分化腺癌的起源部位。
Groups of 50 F344 rats of each sex sere exposed to 0.6 or 3.0 pts/10(6) of 1,2-dibromo-3-chloropropane (DBCP) by inhalation for 6 h/day, 5 days/week for 103 weeks. Fifty rats of each sex inhaling filtered air were used as unexposed controls. All survivors were killed at 104 weeks. Up to 93% of the male and female rats developed neoplasms of the nasal cavity. Most of the tumours were adenomas, squamous-cell papillomas, squamous-cell carcinomas, and adenocarcinomas. In the low-dose group 78% of the tumours in males and 66% in females were benign, whereas in the high-dose groups 89% in males and 76% in females were malignant. Invasion through the cribriform plate into the cerebrum or metastasis to the regional lymph nodes was found in 73% of the carcinomas in males and 51% in females. Electron-microscopic examination suggested that the basal cells of the olfactory epithelium were the site of origin of the poorly differentiated adenocarcinomas.