Association of the intronic rs2072621 polymorphism of the X-linked GPR50 gene with affective disorder with seasonal pattern
Association of the intronic rs2072621 polymorphism of the X-linked GPR50 gene with affective disorder with seasonal pattern
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DOI：
10.1016/j.eurpsy.2011.02.011
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发表时间：
2012-07-01
影响因子：
7.8
通讯作者：
Krebs, M-O
中科院分区：
文献类型：
--
作者：
Delavest, M.;Even, C.;Krebs, M-O
本病例对照研究发现季节性情感障碍（SAD）与女性GPR50（G蛋白偶联褪黑激素受体亚家族的孤儿成员）编码基因的单核苷酸多态性（内含子rs2072621）之间存在关联。这可能代表了一个性别特异性的风险因素和褪黑激素和SAD之间的分子联系。(C)2011年Elsevier Masson SAS。All rights reserved.
This case-control study found an association between Seasonal Affective Disorder (SAD) and a single nucleotide polymorphism (intronic rs2072621) of the gene encoding GPR50 (an orphan member of the G protein-coupled melatonin receptor subfamily) in females. This may represent a gender-specific risk factor and a molecular link between melatonin and SAD. (C) 2011 Elsevier Masson SAS. All rights reserved.