Recent progress in chemical and chemoenzymatic synthesis of carbohydrates.
Recent progress in chemical and chemoenzymatic synthesis of carbohydrates.
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DOI：
10.1016/j.cbpa.2009.09.013
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发表时间：
2009-12
影响因子：
7.8
通讯作者：
Chen, Xi
中科院分区：
文献类型：
--
作者：
Muthana, Saddam;Cao, Hongzhi;Chen, Xi
碳水化合物在生物过程中发挥的重要作用及其在诊断、治疗和疫苗开发中的潜在应用使它们成为有吸引力的合成靶点。尽管面临持续的挑战，近年来碳水化合物的合成仍取得了巨大进展。化学糖基化方法变得更加复杂，寡糖的合成也变得更加可预测。简化的一锅糖基化策略和自动化合成越来越多地用于获得具有生物学重要意义的聚糖。另一方面，化学酶合成仍然是获得复杂碳水化合物的有力替代方案。本综述重点介绍了碳水化合物化学和化学酶合成的最新进展，特别关注低聚糖、多糖、糖脂和糖基化天然产物的合成方法。
The important roles that carbohydrates play in biological processes and their potential application in diagnosis, therapeutics, and vaccine development have made them attractive synthetic targets. Despite ongoing challenges, tremendous progresses have been made in recent years for the synthesis of carbohydrates. The chemical glycosylation methods have become more sophisticated and the synthesis of oligosaccharides has become more predictable. Simplified one-pot glycosylation strategy and automated synthesis are increasingly used to obtain biologically important glycans. On the other hand, chemoenzymatic synthesis continues to be a powerful alternative for obtaining complex carbohydrates. This review highlights recent progress in chemical and chemoenzymatic synthesis of carbohydrates with a particular focus on the methods developed for the synthesis of oligosaccharides, polysaccharides, glycolipids, and glycosylated natural products.
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