Longitudinal analysis of genitourinary and bowel symptoms in prostate cancer patients following brachytherapy.
Longitudinal analysis of genitourinary and bowel symptoms in prostate cancer patients following brachytherapy.
复制标题
近距离放射治疗后前列腺癌患者泌尿生殖和肠道症状的纵向分析。
DOI：
10.1097/coc.0b013e31819cd364
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Barrett,William
中科院分区：
文献类型：
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作者：
Eckman,MarkH;Ying,Jun;Hertzfeld,Kara;Kumar,Nitin;Barrett,William
目的：对于患有局限性前列腺癌的男性，治愈率相似的患者有多种选择。因此，治疗相关的发病率是治疗选择的主要考虑因素。我们在辛辛那提大学的近距离放射治疗登记处对治疗后的泌尿生殖道和肠道症状进行了描述性的纵向分析。方法：1995-2007年间，连续394名新诊断的早期前列腺癌患者接受了放射性125I粒子植入。随访时间为(5.0±3.1)年。结果：40%的男性出现尿路梗阻症状，一般在近距离放射治疗后的前3至6个月内出现。这些症状在很大一部分男性中得到了缓解。有15%的男性在6个月后会出现性欲减退，超过40%的男性会在60个月后出现这种情况。肠道症状较少见，起效较慢。结论：近距离放射治疗后的症状各有其发展和消退的时间模式。治疗性放射损伤和愈合的基本病理生理学很好地解释了这些模式。男性和他们的伴侣可以使用这些信息来指导和告知治疗决定。
Objectives:Multiple options with similar cure rates exist for men with localized adenocarcinoma of the prostate. Therefore, treatment-related morbidity is a major consideration for treatment selection. We present a descriptive, longitudinal analysis of genitourinary and bowel symptoms following treatment in a brachytherapy registry at the University of Cincinnati.Methods:Between 1995 and 2007, 394 consecutive patients with newly diagnosed early stage prostate cancer underwent radioactive 125 I seed implantation. Patients were followed for an average of 5.0±3.1 years. Follow-up data regarding genitourinary and bowel symptoms and clinical/biochemical evidence of cancer recurrence were collected during posttreatment visits.Results:Forty percent of men developed urinary obstructive symptoms, generally within the first 3 to 6 months following brachytherapy. These symptoms resolved in a large proportion of men. Impaired potency occurred in 15% of men by 6 months and in more than 40% of men by 60 months. Bowel symptoms were less common and had a slower onset.Conclusion:Symptoms following brachytherapy each have their own temporal pattern for development and resolution. These patterns are well explained by the underlying pathophysiology of therapeutic radiation injury and healing. Men and their partners can use this information to guide and inform treatment decisions.