Genomes were forged by massive bombardments with retroelements and retrosequences
Genomes were forged by massive bombardments with retroelements and retrosequences
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DOI：
10.1023/a:1004018519722
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发表时间：
1999-01-01
期刊：
影响因子：
1.5
通讯作者：
Brosius, J
中科院分区：
文献类型：
--
作者：
Brosius, J
逆转录是一种有效的途径，以移动基因组周围的编码区“搜索”新的调控元件和鸟枪调控元件进入基因组“搜索”新的靶基因。这种逆转录基因的模板是mRNA，而调节逆转录子（nuon =任何可定义的核酸序列）通常是小的非mRNA。支持SINE（短散布重复元件）的"主基因"模型的一个例子是神经元BC1 RNA。此外，还给出了LINE（长散布重复元素）参与SINE生成的另一种解释。我还认为，转座因子相对于宿主的地位更像是共生关系，而不是寄生关系，宿主的防御往往是宽容的，就好像甚至“容忍或支持”反转子。最后，进化论缺乏远见的悖论和未来对retronuons的过度使用正在通过参考W.F. Doolittle的“基因组进化的层次方法”。
Retroposition is an efficient route to move coding regions around the genome 'in search' of novel regulatory elements and to shotgun regulatory elements into the genome 'in search' of new target genes. The templates for such retrogenes are mRNAs, and for regulatory retronuons (nuon = any definable nucleic acid sequence) usually small non-mRNAs. An example in support of the 'master gene' model for SINEs (short interspersed repetive elements) is provided with neuronal BC1 RNA. Furthermore, an alternative explanation of LINE (long interspersed repetive elements) involvement in the generation of SINEs is given. I will also argue that the status of transposable elements with respect to the host resembles more symbiosis than parasitiasis and that host defense is often lenient as if even to 'tolerate or support' retronuons. Finally the paradox of evolution's lack of foresight and the future exaptive use of retronuons is being dealt with by referring to W.F. Doolittle's 'Hierarchical Approaches to Genome Evolution'.