Induction of indoleamine 2,3-dioxygenase in human cells in vitro.
Induction of indoleamine 2,3-dioxygenase in human cells in vitro.
复制标题
体外人体细胞中吲哚胺 2,3-双加氧酶的诱导。
DOI：
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发表时间：
1991
影响因子：
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通讯作者：
H. Wachter
中科院分区：
文献类型：
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作者：
G. Werner;E. Werner;D. Fuchs;A. Hausen;G. Reibnegger;H. Wachter
干扰素-γ是在体外诱导人细胞IDO最有效的成分。淋巴细胞因子支持其他干扰素的作用。IDO的诱导及各种因素对IDO的影响与蝶啶的合成有关。在某些疾病状态下，体内观察到新喋呤和色氨酸代谢产物的排泄增强，这可能是几种介质的协同作用的原因。
IFN-gamma is the most effective principle responsible for IDO induction in human cells in vitro. Lymphocyte factors support the effect of other IFN species. Induction of IDO and influence of various factors on IDO is correlated to pteridine synthesis. Cooperative effects of several mediators may account for in vivo observations concerning enhanced excretion of neopterin and tryptophan metabolites in certain disease states.