CT visualization of blood pool in rats by using long-circulating, iodine-containing micelles
CT visualization of blood pool in rats by using long-circulating, iodine-containing micelles
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DOI：
10.1016/s1076-6332(99)80063-4
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发表时间：
1999-01-01
影响因子：
4.8
通讯作者：
Wolf, GL
中科院分区：
文献类型：
--
作者：
Torchilin, VP;Frank-Kamenetsky, MD;Wolf, GL
理由和目标。造影剂的小的、长循环的颗粒载体，例如胶束，在计算机断层扫描（CT）血池成像中是潜在有用的。由碘取代的聚-L-赖氨酸（PEG-碘赖氨酸）组成的含碘两亲性嵌段共聚物在水溶液中形成胶束。因此，在大鼠体内研究了这些不透射线胶束的生物分布和CT描绘。PEG-碘赖氨酸胶束，合成并以170 mg碘/kg的剂量通过尾静脉注射到大鼠中。采用3只动物，在连续CT扫描中进行组织增强。PEG-碘赖氨酸嵌段共聚物形成平均直径为80 nm且碘含量为33.8%的颗粒。静脉注射到大鼠后，该代理人产生显着的和持续的增强血池（主动脉和心脏），肝脏，脾脏至少3 hours.Conclusion，在大鼠中，MPEG-碘赖氨酸胶束是一个长寿的血池造影剂CT有用。
Rationale and Objectives. Small, long-circulating particulate carriers of contrast agents, such as micelles, are potentially useful in computed tomographic (CT) blood-pool imaging. An iodine-containing amphiphilic block-copolymer consisting of iodine-substituted poly-L-lysine (MPEG-iodolysine) forms micelles in an aqueous solution. The biodistribution and CT depiction of these radiopaque-Micelles were therefore studied in rats.Materials and Methods. MPEG-iodolysine micelles,synthesized and injected into rats via the tail vein at dose of 170 mg iodine per kilogram. Three animals were used, and tissue enhancement was followed on serial CT scans.Results. MPEG-iodolysine block-copolymer forms particulates with an average diameter of 80 nm and an iodine content of 33.8%. After intravenous injection into rats, the agent produced noticeable and sustained enhancement of the blood pool (aorta and heart), liver, and spleen for least 3 hours.Conclusion,In rats, MPEG-iodolysine micelles were a long-lived blood-pool contrast agent useful for CT.