Chronic Inflammation and Hepatocellular Carcinoma
Chronic Inflammation and Hepatocellular Carcinoma
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DOI：
10.1007/978-3-642-03503-6_8
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Lin, Wey-Ran
中科院分区：
文献类型：
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作者：
Alison, Malcolm R.;Nicholson, Linda J.;Lin, Wey-Ran
肝细胞癌（HCC）总是在由嗜肝病毒、毒素、代谢性肝病或自身免疫引起的慢性炎症中发展。连接这两个过程的机制尚不完全清楚，但NF-kappa B家族的转录因子和信号传感器和转录激活因子3 (STAT3)，细胞因子如IL-6和IL-1 α以及表皮生长因子受体（EGFR）家族的配体显然是关键的参与者。HCC可能起源于肝细胞或肝祖细胞（HPCs），而HCC与其他实体肿瘤一样，似乎是由少数癌症干细胞维持的。
Hepatocellular carcinoma (HCC) invariably develops within a setting of chronic inflammation caused by either hepatotropic viruses, toxins, metabolic liver disease or autoimmunity. Mechanisms that link these two processes are not completely understood, but transcription factors of the NF-kappa B family and signal transducer and activator of transcription 3 (STAT3), cytokines such as IL-6 and IL-1 alpha and ligands of the epidermal growth factor receptor (EGFR) family are clearly pivotal players. HCC may have its origins in either hepatocytes or hepatic progenitor cells (HPCs), and HCCs, like other solid tumours appear to be sustained by a minority population of cancer stem cells.