THE ROLE OF THE DORSOLATERAL PREFRONTAL CORTEX IN RETRIEVAL FROM LONG-TERM MEMORY DEPENDS ON STRATEGIES: A REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION STUDY
THE ROLE OF THE DORSOLATERAL PREFRONTAL CORTEX IN RETRIEVAL FROM LONG-TERM MEMORY DEPENDS ON STRATEGIES: A REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION STUDY
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DOI：
10.1016/j.neuroscience.2009.12.037
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发表时间：
2010-03-17
期刊：
影响因子：
3.3
通讯作者：
Miniussi, C.
中科院分区：
文献类型：
--
作者：
Manenti, R.;Cotelli, M.;Miniussi, C.
在日常生活中，把名字和脸联系起来的能力是一项至关重要的相关任务。在这项研究中，我们利用重复经颅磁刺激（rTMS）在青年受试者的左或右背外侧前额叶皮层（DLPFC）上研究了面孔名称检索的神经元基础。实验任务分为两个学习阶段：编码阶段和检索阶段。在编码阶段，受试者看到一张面孔（熟悉的或不熟悉的）后面跟着一个名字。在检索阶段，他们同时看到这张脸和两个名字，并必须选择与这张脸正确相关的名字。rTMS仅在检索时进行。此外，我们评估了任务期间记忆策略的使用情况。据此，被试被细分为两组：策略使用者（SU）和无策略使用者（NSU）。对于熟悉的面孔-名字对，没有rTMS效应，可能是由于天花板效应。然而，对于不熟悉的面孔-名字对，不同的记忆策略使用导致了不同的rTMS效应。SU组在右侧DLPFC刺激后出现选择性干扰效应，而NSU组在左侧DLPFC刺激后出现选择性干扰效应。重要的是，两组的整体表现是相似的。我们认为，在记忆提取过程中，当被试不刻意使用检索策略时，左侧DLPFC可能会被调动，而当被试需要策略参与的认知控制过程来指导情景检索时，右侧DLPFC会被调动。(c) 2010 ibro。Elsevier Ltd.出版。版权所有。
The ability to associate a name to a face is a crucially relevant task in daily life. In this study, we investigated the neuronal basis of face-name retrieval in young subjects using repetitive transcranial magnetic stimulation (rTMS) over the left or right dorsolateral prefrontal cortex (DLPFC). The experimental task was composed of two study phases: an encoding phase and a retrieval phase. During the encoding phase, subjects saw a face (familiar or unfamiliar) followed by a name. During the retrieval phase, they saw the face together with two names and had to choose the name that was correctly associated with the face. rTMS was delivered only during retrieval. In addition, we evaluated the use of memory strategies during the task. Accordingly, subjects were subdivided into two groups: strategy users (SU) and no-strategy users (NSU). No rTMS effects were present for familiar face-name pairs, probably due to a ceiling effect. However, for unfamiliar face-name pairs, the different use of memory strategies resulted in different rTMS effects. The SU group showed a selective interference effect after right DLPFC stimulation, whereas the NSU group showed an effect after left DLPFC stimulation. Importantly, the overall performance of the two groups was comparable. We suggest that during memory retrieval the left DLPFC might be recruited when the subject does not apply deliberately a retrieval strategy whereas there is a shift to the right DLPFC if cognitive control processes that are engaged by strategies are needed to guide episodic retrieval. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.