Impact of a National Controlled Donation After Circulatory Death (DCD) Program on Organ Donation in the United Kingdom: A 10-Year Study
Impact of a National Controlled Donation After Circulatory Death (DCD) Program on Organ Donation in the United Kingdom: A 10-Year Study
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DOI：
10.1111/ajt.14374
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发表时间：
2017-12-01
影响因子：
8.8
通讯作者：
Lodge, J. P. A.
中科院分区：
文献类型：
--
作者：
Hodgson, R.;Young, A. L.;Lodge, J. P. A.
器官移植是治疗某些形式的器官衰竭最成功的方法，然而，器官的缺乏意味着许多人在等待名单上死去。在英国，器官捐赠特别工作组成立，以确定器官捐赠的障碍，并于2008年发布了第一份报告(器官捐赠特别工作组报告；ODTR)。这项研究评估了自ODTR以来的成功，并检查了英国循环死亡后受控捐赠(DCD)计划的影响以及围绕该计划的争议。从2004年4月到2014年3月，有12864名脑死亡或脑死亡捐赠者打算捐献。与前5年和后5年相比，DCD捐赠者增加了292%(1187人增至4652人)，DBD捐赠者增加了11%(3327人至3698人)。每个DBD捐献者的器官取回保持不变(3.30到3.26)，而DCD减少(1.54到0.99)，这是因为没有进行捐赠的捐赠者大幅增加(325到2464)。大多数DCD捐赠者在撤资后30分钟内这样做。我们的研究建议进一步将符合条件的转诊转化为器官捐赠，并探索将DCD转化为DBD捐赠者的方法。
Organ transplantation is the most successful treatment for some forms of organ failure, yet a lack of organs means many die on the waiting list. In the United Kingdom, the Organ Donation Taskforce was set up to identify barriers to organ donation and in 2008 released its first report (Organ Donation Taskforce Report; ODTR). This study assesses the success since the ODTR and examines the impact of the United Kingdom's controlled donation after circulatory death (DCD) program and the controversies surrounding it. There were 12864 intended donation after brain death (DBD) or DCD donors from April 2004 to March 2014. When the 5years preceding the ODTR was compared to the 5years following, intended DCD donors increased 292% (1187 to 4652), and intended DBD donors increased 11% (3327 to 3698). Organs retrieved per intended DBD donor remained static (3.30 to 3.26), whereas there was a decrease in DCD (1.54 to 0.99) due to a large rise in donors who did not proceed to donation (325 to 2464). The majority of DCD donors who proceeded did so within 30min from time of withdrawal. Our study suggests further work on converting eligible referrals to organ donation and exploring methods of converting DCD to DBD donors.