Antileishmanial effect of allopurinol. II. Relationship of adenine metabolism in Leishmania species to the action of allopurinol.
Antileishmanial effect of allopurinol. II. Relationship of adenine metabolism in Leishmania species to the action of allopurinol.
复制标题
别嘌呤醇的抗利什曼效应。
DOI：
10.1093/infdis/136.6.724
复制
发表时间：
1977
期刊：
影响因子：
--
通讯作者：
R. L. Berens
中科院分区：
文献类型：
--
作者：
J. Marr;R. L. Berens
别嘌呤醇在体外对墨西哥利什曼原虫和多诺瓦利什曼原虫以及巴西利什曼原虫均有效。别嘌呤醇在人体内的主要代谢衍生物，氧化嘌呤醇，也对多诺瓦杆菌具有抗利什曼病的作用。别嘌呤醇和氧化嘌呤醇的抗利什曼病作用可被腺嘌呤及其代谢前体和衍生物特异性逆转，但不能被其他嘌呤及其衍生物特异性逆转。有人提出，腺嘌呤琥珀酸合成酶或腺嘌呤磷酸核糖基转移酶可能是这些药物的作用位点。
Allopurinol was shown to be effective in vitro against Leishmania mexicana and Leishmania donovani as well as against Leishmania braziliensis. The major metabolic derivative of allopurinol in humans, oxipurinol, also is antileishmanial for L. donovani. The antileishmanial effect of allopurinol and oxipurinol can be specifically reversed by adenine, and its metabolic precursors and derivatives, but by no other purines or their derivative. It is proposed that the adenylosuccinate synthetase or the adenine phosphoribosyltransferase may be sites of action for these agents.