A DERATING METHOD FOR THERAPEUTIC APPLICATIONS OF HIGH INTENSITY FOCUSED ULTRASOUND.
A DERATING METHOD FOR THERAPEUTIC APPLICATIONS OF HIGH INTENSITY FOCUSED ULTRASOUND.
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DOI：
10.1134/s1063771010030140
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发表时间：
2010-01-01
影响因子：
0.8
通讯作者：
Crum LA
中科院分区：
文献类型：
--
作者：
Bessonova OV;Khokhlova VA;Canney MS;Bailey MR;Crum LA
目前确定组织中高强度聚焦超声(HIFU)场的方法依赖于假设线性波在水中和组织中传播的水中测量的外推。在降级过程中忽略非线性传播效应可能会导致显著的误差。在这项工作中，提出了一种新的基于源幅度尺度的方法来估计组织中非线性HIFU场的焦参数。从KZK型方程的数值解中得到了吸收组织中声场参数的焦点值，并与水中传播的模拟结果进行了比较。焦点波形、峰值压力和强度是在广泛的震源输出和线性聚焦增益范围内计算的。我们的模型表明，对于治疗医学应用中通常使用的高增益源，用我们的方法得到的焦场参数与组织中的数值模拟结果吻合得很好。实验证明了该方法在牛肝组织中应用的可行性。
Current methods of determining high intensity focused ultrasound (HIFU) fields in tissue rely on extrapolation of measurements in water assuming linear wave propagation both in water and in tissue. Neglecting nonlinear propagation effects in the derating process can result in significant errors. In this work, a new method based on scaling the source amplitude is introduced to estimate focal parameters of nonlinear HIFU fields in tissue. Focal values of acoustic field parameters in absorptive tissue are obtained from a numerical solution to a KZK-type equation and are compared to those simulated for propagation in water. Focal waveforms, peak pressures, and intensities are calculated over a wide range of source outputs and linear focusing gains. Our modeling indicates, that for the high gain sources which are typically used in therapeutic medical applications, the focal field parameters derated with our method agree well with numerical simulation in tissue. The feasibility of the derating method is demonstrated experimentally in excised bovine liver tissue.
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影响因子：
2.4
作者：
Khokhlova, VA;Souchon, R;Cathignol, D
通讯作者：
Cathignol, D
影响因子：
2.9
作者：
Duck, FA
通讯作者：
Duck, FA
影响因子：
2.9
作者：
Canney, Michael S.;Khokhlova, Vera A.;Bessonova, Olga V.;Bailey, Michael R.;Crum, Lawrence A.
通讯作者：
Crum, Lawrence A.
影响因子：
0.8
作者：
Bessonova OV;Khokhlova VA;Bailey MR;Canney MS;Crum LA
通讯作者：
Crum LA
影响因子：
2.9
作者：
Christopher, T;Carstensen, EL
通讯作者：
Carstensen, EL