Influence of a curcumin derivative on hIAPP aggregation in the absence and presence of lipid membranes.
Influence of a curcumin derivative on hIAPP aggregation in the absence and presence of lipid membranes.
复制标题
在不存在和存在脂质膜的情况下，姜黄素衍生物对HIAPP聚集的影响。
DOI：
10.1039/c5cc07792c
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发表时间：
2016-01-18
期刊：
影响因子：
--
通讯作者：
Ramamoorthy A
中科院分区：
文献类型：
--
作者：
Pithadia AS;Bhunia A;Sribalan R;Padmini V;Fierke CA;Ramamoorthy A
人类胰岛多肽（HIAPP）的聚集与II型糖尿病中的β细胞死亡有关伊普。此处是水溶性姜黄素衍生物Curdac，用于研究在不存在和存在脂质膜的情况下HIAPP聚集的缓解。
The deposition of aggregates of human islet amyloid polypeptide (hIAPP) has been correlated with the death of β-cells in type II diabetes mellitus. The actual molecular mechanism of cell death remains largely unknown; however, it has been postulated that the process of aggregation from monomeric hIAPP is closely involved. A possible cause of cellular toxicity may be through the disruption of structural integrity of the cell membrane by IAPP. Herein, a water-soluble curcumin derivative, CurDAc, is used to investigate the mitigation of hIAPP aggregation in the absence and presence of lipid membrane.