The Panton-Valentine leukocidin vaccine protects mice against lung and skin infections caused by Staphylococcus aureus USA300.
The Panton-Valentine leukocidin vaccine protects mice against lung and skin infections caused by Staphylococcus aureus USA300.
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DOI：
10.1111/j.1469-0691.2008.02648.x
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发表时间：
2009-02
期刊：
影响因子：
--
通讯作者：
Bowden MG
中科院分区：
文献类型：
--
作者：
Brown EL;Dumitrescu O;Thomas D;Badiou C;Koers EM;Choudhury P;Vazquez V;Etienne J;Lina G;Vandenesch F;Bowden MG
耐甲氧西林金黄色葡萄球菌日益成为社区葡萄球菌感染的原因。在美国，社区获得性甲氧西林耐药(CA-MRSA)菌株中有很大比例产生与严重感染相关的潘通-瓦伦丁杀白素(PVL)。比较了CA-MRSA临床株USA300的毒力和其PVL缺失突变株的毒力，结果表明PVL在小鼠坏死性肺炎和皮肤感染模型中分别对肺和肌肉组织造成破坏。感染USA300菌株的小鼠表现出显性的抗PVL反应。因此，PVL亚基被测试为针对该分离株的疫苗原，其疫苗效力与接种途径和感染途径有关。这些数据表明PVL在小鼠CA-MRSA感染中是一个毒力因子。
Methicillin-resistant Staphylococcus aureus is increasingly responsible for staphylococcal infections in the community. A large percentage of the community-acquired methicillin-resistant (CA-MRSA) strains in the USA produce Panton–Valentine leukocidin (PVL), which is associated with severe infections. The virulence of the clinical CA-MRSA strain USA300 was compared to that of its isogenic pvl-deleted mutant, and it was shown that PVL contributes to lung and muscle tissue destruction, respectively, in murine necrotizing pneumonia and skin infection models. Mice infected with the USA300 strain developed a dominant anti-PVL response. The PVL subunits were therefore tested as vaccinogens against this isolate, and their vaccine efficacy correlated with both the route of vaccination and infection. These data suggest that PVL is a virulence factor in murine CA-MRSA infections.
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