Hendra virus vaccine, a one health approach to protecting horse, human, and environmental health.
Hendra virus vaccine, a one health approach to protecting horse, human, and environmental health.
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DOI：
10.3201/eid2003.131159
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发表时间：
2014-03
影响因子：
11.8
通讯作者：
Wang LF
中科院分区：
文献类型：
--
作者：
Middleton D;Pallister J;Klein R;Feng YR;Haining J;Arkinstall R;Frazer L;Huang JA;Edwards N;Wareing M;Elhay M;Hashmi Z;Bingham J;Yamada M;Johnson D;White J;Foord A;Heine HG;Marsh GA;Broder CC;Wang LF
近年来，人类出现了几种高致病性人畜共患疾病，这使得人们重新强调人类、动物和环境卫生的相互联系，也就是所谓的“同一个健康”。例如，1994年发现了人畜共患副粘病毒亨德拉病毒（HeV），自那时以来，已有7人感染，每个人都与受类似感染的马有很强的流行病学联系。由于这些暴发，讨论了消灭蝙蝠种群的问题，尽管它们在授粉和减少昆虫种群方面具有关键的环境作用。我们描述了一种马用疫苗的开发和评估，该疫苗有可能打破从蝙蝠到马再到人类的HeV传播链，从而保护马、人类和环境健康。马用戊肝病毒疫苗是“同一个健康”控制人类疾病方法的一个重要例子。
In recent years, the emergence of several highly pathogenic zoonotic diseases in humans has led to a renewed emphasis on the interconnectedness of human, animal, and environmental health, otherwise known as One Health. For example, Hendra virus (HeV), a zoonotic paramyxovirus, was discovered in 1994, and since then, infections have occurred in 7 humans, each of whom had a strong epidemiologic link to similarly affected horses. As a consequence of these outbreaks, eradication of bat populations was discussed, despite their crucial environmental roles in pollination and reduction of the insect population. We describe the development and evaluation of a vaccine for horses with the potential for breaking the chain of HeV transmission from bats to horses to humans, thereby protecting horse, human, and environmental health. The HeV vaccine for horses is a key example of a One Health approach to the control of human disease.