Relationship between maximum standardized uptake value (SUVmax) of lung cancer and lymph node metastasis on FDG-PET
Relationship between maximum standardized uptake value (SUVmax) of lung cancer and lymph node metastasis on FDG-PET
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DOI：
10.1007/s12149-009-0237-5
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发表时间：
2009-05-01
影响因子：
2.6
通讯作者：
Araki, Tsutomu
中科院分区：
文献类型：
--
作者：
Nambu, Atsushi;Kato, Satoshi;Araki, Tsutomu
目的探讨原发性肺癌FDG-PET SUVmax与淋巴结转移的关系。研究对象为2004年10月至2008年1月期间连续接受FDG-PET检查并随后接受手术的肺癌患者共66例。其中男41例，女25例，年龄45～83岁，平均68岁。肺癌病理亚型包括腺癌49例、鳞状细胞癌11例、腺鳞癌2例、大细胞癌1例、小细胞癌1例、多形性癌1例、粘液表皮样癌1例。我们统计比较了（1）有和无淋巴结转移组之间的肺癌平均SUVmax（2）根据肺癌中位SUVmax分类的肺癌SUVmax高低组之间的淋巴结转移频率，以及（3）评估了肺癌SUVmax与淋巴结转移频率之间的关系，以及（4）肺癌SUVmax与转移淋巴结数量和病理n分期之间的相关性。有和无淋巴结转移病例之间肺癌SUVmax平均值有统计学意义（p=0.00513）。 SUVmax较高的肺癌组(17/33,52%)淋巴结转移多于SUVmax较低的肺癌组(7/33,21%),差异有统计学意义。肺癌SUVmax小于2.5的肺癌无淋巴结转移，肺癌SUVmax大于12的肺癌有70%的淋巴结转移。肺癌SUVmax与转移淋巴结数量(gamma = 0.404, p = 0.001)和病理n分期(gamma = 0.411, p = 0.001)之间存在中度相关性。原发性肺癌SUV越大，淋巴结转移的可能性越大。
To evaluate the relationship between SUVmax of primary lung cancers on FDG-PET and lymph node metastasis.The subjects were a total of consecutive 66 patients with lung cancer who were examined by FDG-PET and subsequently underwent surgery between October 2004 and January 2008. There were 41 males and 25 females, ranging in age from 45 to 83 years with an average of 68 years. The pathological subtypes of the lung cancers consisted of 49 adenocarcinomas, 11 squamous cell carcinomas, 2 adenosquamous carcinoma, 1 large cell carcinoma, 1 small cell carcinoma, 1 pleomorphic carcinoma and 1 mucoepidermoid carcinoma. We statistically compared (1) the mean SUVmax of lung cancer between the groups with and without lymph node metastasis (2) the frequency of lymph node metastasis between higher and lower SUVmax of lung cancer groups that were classified by using the median SUVmax of lung cancer, and (3) evaluated the relationship between the SUVmax of lung cancer and frequency of lymph node metastases, and (4) correlations between the SUVmax of lung cancer and number of the metastatic lymph nodes and pathological n stages.The difference in the average of the SUVmax of lung cancer between the cases with and without lymph node metastases was statistically significant (p = 0.00513). Lymph node metastasis was more frequently seen in the higher SUVmax of lung cancer group (17/33, 52%) than in the lower SUVmax of lung cancer group (7/33, 21%) with a statistically significant difference. There was no lymph node metastasis in lung cancers with an SUVmax of lung cancer less than 2.5, and lung cancers with an SUVmax of lung cancer more than 12 had a 70% frequency of lymph node metastasis. There were moderate correlations between SUVmax of lung cancer, and the number of the metastatic lymph nodes (gamma = 0.404, p = 0.001) and pathological n stage (gamma = 0.411, p = 0.001).The likelihood of lymph node metastasis increases with an increase of the SUV of a primary lung cancer.