Poly(phosphonate)s via Olefin Metathesis: Adjusting Hydrophobicity and Morphology
Poly(phosphonate)s via Olefin Metathesis: Adjusting Hydrophobicity and Morphology
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DOI：
10.1021/ma5013286
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发表时间：
2014-07
期刊：
影响因子：
5.5
通讯作者：
T. Steinbach;E. Alexandrino;C. Wahlen;K. Landfester;F. Wurm
中科院分区：
文献类型：
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作者：
T. Steinbach;E. Alexandrino;C. Wahlen;K. Landfester;F. Wurm
采用烯烃复分解逐步增长（ADMET）和链增长（开环复分解）聚合法制备了亲水性可变的线性聚膦酸酯。第一膦酸酯单体，即，二（十一碳-10-烯-1-基）甲基膦酸酯用于ADMET聚合，制备了分子量高达23 000 g mol-1、分子量分散度小于2. 5的可降解、生物相容的不饱和聚膦酸酯。研究了这些聚合物与磷酸钙骨替代材料的相互作用，所述磷酸钙骨替代材料来自通过溶剂蒸发细乳液方案制备的水性纳米颗粒分散体。采用开环易位聚合（ROMP）方法，以一种新型的七元环状膦酸酯单体，2-甲基-4，7-二氢-1，3，2-二氧磷杂庚因2-氧化物，以及具有顺式-环辛烯的疏水结晶共聚物。ROMP yiel.
Olefin metathesis step-growth (acyclic diene metathesis (ADMET)) and chain-growth (ring-opening metathesis) polymerization was used to prepare linear poly(phosphonate)s with variable hydrophilicity. The first phosphonate monomer, i.e., di(undec-10-en-1-yl) methylphosphonate, for ADMET polymerization was developed, and potentially degradable and biocompatible, unsaturated poly(phosphonate)s were prepared with molecular weights up to 23 000 g mol–1 with molecular weight dispersities Đ < 2. These polymers were studied with respect to their interaction with a calcium phosphate bone substitute material from an aqueous nanoparticle dispersion that was prepared by a solvent evaporation miniemulsion protocol. Ring-opening metathesis polymerization (ROMP) was employed to synthesize more hydrophilic amorphous polyphosphonates from a novel seven-membered cyclic phosphonate monomer, i.e., 2-methyl-4,7-dihydro-1,3,2-dioxaphosphepine 2-oxide, as well as hydrophobic crystalline copolymers with cis-cyclooctene. ROMP yiel...