Abnormal amygdala function in Parkinson's disease patients and its relationship to depression
Abnormal amygdala function in Parkinson's disease patients and its relationship to depression
复制标题
帕金森病患者杏仁核功能异常及其与抑郁的关系
DOI：
10.1016/j.jad.2015.05.029
复制
发表时间：
2015-09-01
影响因子：
6.6
通讯作者：
Zhang, Minming
中科院分区：
文献类型：
--
作者：
Huang, Peiyu;Xuan, Min;Zhang, Minming
抑郁症是帕金森病（PD）患者的常见病。因此，这两种疾病可能有共同的神经机制。路易体积聚在PD患者的特定脑区可能损害情绪相关功能，导致抑郁。在这些区域中，杏仁核可能在PD中最早出现损伤。然而，杏仁核的结构和功能变化是否与PD患者的抑郁有关尚不清楚。我们招募了19名抑郁症PD患者，19名非抑郁症PD患者和28名正常对照。对所有患者进行临床评估，包括统一帕金森病评定量表、汉密尔顿抑郁评定量表和简易精神状态检查。还获得了结构和静息状态功能脑图像，以评估患者杏仁核的体积和功能变化。结果显示，PD组左杏仁核活动虽无明显体积变化，但与正常对照组相比有所增加，且与汉密尔顿抑郁量表评分相关。此外，与非抑郁症PD患者相比，抑郁症PD患者的右杏仁核和额顶叶区域之间的功能连通性有所下降。这些结果表明，杏仁核功能异常可能是PD患者抑郁发生的基础。(C) 2015 Elsevier B.V.版权所有
Depression is a common occurrence in patients with Parkinson's disease (PD). Thus, there may be a common neural mechanism underlying the two diseases. Lewy body accumulation in specific brain areas of PD patients may damage emotion-related functions, leading to depression. Among these areas, the amygdala may present with the earliest to be damaged in PD. However, it is still unclear whether amygdala structural and functional changes are related to depression in PD. We enrolled 19 depressed PD patients, 19 non-depressed PD patients, and 28 normal control subjects. Clinical assessment, including the Unified Parkinson's Disease Rating Scale, the Hamilton Rating Scale for Depression, and the Mini-Mental State Examination, was carried out on all the patients. Structural and resting-state functional brain images were also acquired to assess volumetric and functional changes of the amygdala in the patients. Results showed that although there is no significant volume change, left amygdala activity increased in the PD group compared with the normal control group, and it correlated with Hamilton Rating Scale for Depression scores. Furthermore, functional connectivity between the right amygdala and fronto-parietal areas was found to be decreased in the depressed PD patients compared with non-depressed PD patients. These results suggest that abnormal amygdala function may underlie the occurrence of depression in PD. (C) 2015 Elsevier B.V. All rights reserved,