Interaction of Adipocyte Metabolic and Immune Functions Through TBK1.
Interaction of Adipocyte Metabolic and Immune Functions Through TBK1.
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DOI：
10.3389/fimmu.2020.592949
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发表时间：
2020
影响因子：
7.3
通讯作者：
Saltiel AR
中科院分区：
文献类型：
--
作者：
Zhao P;Saltiel AR
脂肪细胞和脂肪组织在代谢稳态的调节中起关键作用。在肥胖和肥胖相关的代谢疾病中，免疫细胞浸润到脂肪组织中。脂肪细胞和免疫细胞之间的相互作用重塑了脂肪组织的代谢和免疫特性，并显著改变了代谢设定点。非经典IKK家族成员TBK 1的表达和活性在饮食诱导的肥胖期间在脂肪组织中被诱导。TBK 1在脂肪组织的代谢和炎症调节中起重要作用，从而影响葡萄糖和能量代谢。本文综述了TBK 1的调控和功能，以及TBK 1调控脂肪组织代谢和炎症的分子机制。最后，我们讨论了TBK 1/IKKε抑制剂作为代谢性疾病新疗法的潜力。
Adipocytes and adipose tissue play critical roles in the regulation of metabolic homeostasis. In obesity and obesity-associated metabolic diseases, immune cells infiltrate into adipose tissues. Interaction between adipocytes and immune cells re-shapes both metabolic and immune properties of adipose tissue and dramatically changes metabolic set points. Both the expression and activity of the non-canonical IKK family member TBK1 are induced in adipose tissues during diet-induced obesity. TBK1 plays important roles in the regulation of both metabolism and inflammation in adipose tissue and thus affects glucose and energy metabolism. Here we review the regulation and functions of TBK1 and the molecular mechanisms by which TBK1 regulates both metabolism and inflammation in adipose tissue. Finally, we discuss the potential of a TBK1/IKKε inhibitor as a new therapy for metabolic diseases.