Genetic analysis of non-insulin-dependent diabetes mellitus in the Otsuka Long-Evans Tokushima Fatty rat.
Genetic analysis of non-insulin-dependent diabetes mellitus in the Otsuka Long-Evans Tokushima Fatty rat.
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大冢朗-埃文斯德岛脂肪大鼠非胰岛素依赖型糖尿病的遗传分析。
DOI：
10.1006/bbrc.1997.7347
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发表时间：
1997
影响因子：
3.1
通讯作者：
Y. Yamori
中科院分区：
文献类型：
--
作者：
Y. Nara;M. Gao;K. Ikeda;T. Sato;M. Sawamura;K. Kawano;Y. Yamori
大冢Long-Evans Tokushima Fatty(OLETF)大鼠是肥胖型NIDDM的动物模型。我们对OLETF大鼠与两个对照品系Long-Evans Tokushima Otsuka(LETO)和Fisher-344(F-344)杂交得到的F2后代进行了全基因组扫描。由于糖尿病只发生在雄性后代中，我们只用雄性F2大鼠进行连锁研究，发现表型、餐后高血糖与1号染色体上的P-450ald基因座和7号染色体上的D7Mit 11基因座之间存在显著的连锁关系，此外，空腹血糖水平和体重与这两个基因座之间也存在显著的连锁关系。染色体1、2、5和17上的另外四个区域(D1Mit12、D2Mit11、D5Mgh14和D17Arb1)被检测到独立地影响体重、空腹血糖水平或餐后高血糖。我们的结论是，OLETF大鼠的非胰岛素依赖型糖尿病(NIDDM)是由多个基因调控的，这些基因对空腹、餐后高血糖和肥胖有不同的影响。
The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese NIDDM. We performed a genome wide scan in F2 progenies obtained by crossing OLETF rats with two control strains, Long-Evans Tokushima Otsuka (LETO) and Fisher-344(F-344) rats. Since diabetes develops only in male progenies, we used only male F2 rats for the linkage studies.Highly significant linkage was observed between the phenotype, postprandial hyperglycemia and P-450ald locus on chromosome 1 and D7Mit 11 locus on chromosome 7. In addition, suggestive linkage was found between fasting glucose level and body weight and these two loci. Four other regions (D1Mit12, D2Mit11, D5Mgh14, and D17Arb1) on chromosome 1, 2, 5, and 17 were detected to influence body weight, fasting glucose level or postprandial hyperglycemia independently. We concluded that non-insulin-dependent diabetes mellitus(NIDDM) in OLETF rats is regulated by multiple genes which affect fasting, postprandial hyperglycemia, and obesity differently.
影响因子：
158.5
作者：
FROGUEL, P;ZOUALI, H;COHEN, D
通讯作者：
COHEN, D