The effect of long noncoding RNAs HOX transcript antisense intergenic RNA single-nucleotide polymorphisms on breast cancer, cervical cancer, and ovarian cancer susceptibility: A meta-analysis
The effect of long noncoding RNAs HOX transcript antisense intergenic RNA single-nucleotide polymorphisms on breast cancer, cervical cancer, and ovarian cancer susceptibility: A meta-analysis
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DOI：
10.1002/jcb.27975
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发表时间：
2019-05-01
影响因子：
4
通讯作者：
Sun, Changgang
中科院分区：
文献类型：
--
作者：
Li, Jia;Liu, Ruijuan;Sun, Changgang
最近的研究表明，长链非编码RNA（lncRNA）HOX转录反义基因间RNA（HOTAIR）多态性与癌症易感性相关。在各种癌症中，对妇女健康威胁最大的是乳腺癌（BC）、宫颈癌（CC）和卵巢癌（OC），其发病率正在上升。我们进行了一项荟萃分析，以阐明lncRNA HOTAIR表达与BC、CC和OC易感性之间的关系。我们彻底检索了PubMed、Embase和科克伦图书馆以获得相关文献。我们从病例组和对照组中提取了每个单核苷酸多态性（SNP）（rs 4759314，rs 920778，rs 189663，rs 12826786，rs7958904和rs 874945）的数据，并比较了等位基因，共显性模型，显性和隐形模型与BC，CC和OC易感性之间的关系。我们的研究包括11项研究，共5322例患者。HOTAIR基因rs 4759314多态性与BC、CC和OC的易感性显著相关（共显性模型：AG/AA比值比[OR] = 1.13 [95%置信区间[CI]，1.00-1.29]，GG/AA OR = 1.54 [95% CI，1.06-2.23];显性模型：GG + AG/AA OR = 1.16 [95%CI，1.02-1.32];隐性模型：GG/AA + AG OR = 1.51 [95%CI，1.05-2.19]）。rs 920778的表达与BC、CC和OC的易感性之间的关系尚不清楚（等位基因T/C：OR = 1.28 [95% CI，0.87-1.89];共显性模型：CT/CC OR = 1.10 [95% CI，0.71-1.71]，TT/CC OR = 1.29 [95% CI，0.59-2.80];显性模型：隐性模型：TT/TC + CC OR = 1.43，95%CI为0.83-2.47）。HOTAIR基因rs 1899663多态性在一定程度上与BC、CC和OC的易感性相关，（等位基因T/G OR = 0.90 [95% CI，0.69-1.16];共显性模型：GT/GG OR = 0.81 [95% CI，0.50-1.30]，TT/GG OR = 1.04 [95% CI，0.63-1.72];显性模型：GT + TT/GG OR = 0.82 [95%CI，0.52-1.29];隐性模型：TT/GT + GG OR = 1.21 [95%CI，0.76-1.94]）。rs 12826786、rs7958904和rs 874945多态性与BC、CC和OC的易感性存在一定程度的相关性，但无统计学意义。HOTAIR rs 4759314增加了某些患者对BC、CC和OC的易感性; rs 029778和rs 1899663也在一定程度上增加了易感性。SNPs rs 12826786、rs7958904和rs 874945与患者对BC、CC和OC的易感性无关。
Recent studies have shown that long noncoding RNAs (lncRNA) HOX transcript antisense intergenic RNA (HOTAIR) polymorphisms are associated with cancer susceptibility. The greatest threat to women's health among a variety of cancers is breast cancer (BC), cervical cancer (CC), and ovarian cancer (OC), and the incidence of it is increasing. We performed a meta-analysis to clarify the relationship between lncRNA HOTAIR expression and BC, CC, and OC susceptibility. We thoroughly searched PubMed, Embase, and the Cochrane Library to obtain the relevant literature. We extracted data from case groups and control groups for each single-nucleotide polymorphism (SNP) (rs4759314, rs920778, rs189663, rs12826786, rs7958904, and rs874945) and compared the relationship between alleles, codominance models, dominant and invisible models and BC, CC, and OC susceptibility. Our study included 11 studies with a total of 5322 patients. There was a significant association between the rs4759314 polymorphism of HOTAIR and susceptibility to BC, CC, and OC (codominant model: AG/AA odds ratio [OR] = 1.13 [95% confidence intervals [CI], 1.00-1.29], GG/AA OR = 1.54 [95% CI, 1.06-2.23]; dominant model: GG + AG/AA OR = 1.16 [95% CI, 1.02-1.32]; and recessive model: GG/AA + AG OR = 1.51 [95% CI, 1.05-2.19]). The association between the expression of rs920778 and BC, CC, and OC susceptibility was not clear (alleles T/C: OR = 1.28 [95% CI, 0.87-1.89]; in codominant model: CT/CC OR = 1.10, [95% CI, 0.71-1.71], TT/CC OR = 1.29 [95% CI, 0.59-2.80]; dominant model: TC + TT/CC OR = 1.16, [95% CI, 0.73-1.86]; and recessive model: TT/TC + CC OR = 1.43, [95% CI, 0.83-2.47]). HOTAIR polymorphism rs1899663 was associated with BC, CC, and OC susceptibility to a certain extent, (alleles T/G OR = 0.90 [95% CI, 0.69-1.16]; in the codominant model: GT/GG OR = 0.81 [95% CI, 0.50-1.30], TT/GG OR = 1.04 [95% CI, 0.63-1.72]; dominant model: GT + TT/GG OR = 0.82 [95% CI, 0.52-1.29]; and recessive model: TT/GT + GG OR = 1.21 [95% CI, 0.76-1.94]). The rs12826786, rs7958904, and rs874945 polymorphisms were associated with a certain degree of BC, CC, and OC susceptibility, but they were not statistically significant. HOTAIR rs4759314 increased susceptibility to BC, CC, and OC in some patients; rs029778 and rs1899663 also increased susceptibility to some extent. SNPs rs12826786, rs7958904, and rs874945 did not correlate with an effect on patient susceptibility to BC, CC, and OC.