Diabetes and idiopathic cardiomyopathy - A nationwide case-control study
Diabetes and idiopathic cardiomyopathy - A nationwide case-control study
复制标题
DOI：
10.2337/diacare.26.10.2791
复制
发表时间：
2003-10-01
期刊：
影响因子：
16.2
通讯作者：
Brancati, FL
中科院分区：
文献类型：
--
作者：
Bertoni, AG;Tsai, A;Brancati, FL
目的：关于糖尿病与非缺血性特发性心肌病（ICM）之间的关系存在争议，并且只有有限的数据可用于成人糖尿病患者的ICM发病率。因此，我们使用1995年全国住院患者样本（NIS）来确定出院率，并检验糖尿病与ICM独立相关的假设。研究设计和方法- 1995年国家信息系统包括19个州900家代表性医院的所有出院情况的人口统计和诊断数据。ICD-9代码用于识别ICM，定义为诊断为原发性心肌病但没有确定的心肌病危险因素的出院患者。对照组按年龄分层随机抽样，每例ICM病例10例。分析的协变量包括年龄、种族、收入中位数、糖尿病和高血压。采用多因素logistic回归进行病例-对照分析。结果-使用抽样权重，我们估计在1995年，诊断为糖尿病的个体中，ICM的出院率为7.6 / 1000。44,837名ICM组糖尿病患病率明显高于450,254名对照组（26.6% vs. 17.2%），相对危险度（RO）为1.75 （95% CI 1.71-1.79）。在调整了年龄、性别、种族、高血压和收入中位数后，使用多元logistic回归，糖尿病仍然与ICM显著相关（RO 1.58, 95% Cl 1.55-1.62）。结论：我们的结论是，在美国一般人群中，糖尿病与ICM独立相关。
OBJECTIVE - Controversy exists regarding the relation between diabetes and nonischemic idiopathic cardiomyopathy (ICM), and only limited data on the incidence of ICM in adults with diabetes are available. Therefore, we used the 1995 Nationwide Inpatient Sample (NIS) to determine discharge rates and test the hypothesis that diabetes is independently associated with ICM.RESEARCH DESIGN AND METHODS - The 1995 NIS includes demographic and diagnostic data on all discharges from >900 representative hospitals in 19 states. ICD-9 codes were used to identify ICM, defined as discharges with a diagnosis of primary cardiomyopathy but without established risk factors for cardiomyopathy. Control subjects were selected by stratified random sampling by age to yield 10 per ICM case. The analyzed covariates included age, race, median income, diabetes, and hypertension. Multivariate logistic regression was used to conduct case-control analyses.RESULTS - Using sampling weights, we estimated that in 1995, the rate of hospital discharge for ICM among individuals diagnosed with diabetes was 7.6 per 1,000. The prevalence of diabetes was substantially higher in the 44,837 ICM vs. 450,254 control subjects (26.6 vs. 17.2%), corresponding to a relative odds (RO) of 1.75 (95% CI 1.71-1.79). After adjusting for age, sex, race, hypertension, and median income using multiple logistic regression, diabetes remained significantly associated with ICM (RO 1.58, 95% Cl 1.55-1.62).CONCLUSIONS - We concluded that diabetes is independently associated with ICM in the general U.S. population.