DIETARY BETA-CAROTENE AND LUNG-CANCER RISK IN UNITED-STATES NONSMOKERS
DIETARY BETA-CAROTENE AND LUNG-CANCER RISK IN UNITED-STATES NONSMOKERS
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DOI：
10.1093/jnci/86.1.33
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发表时间：
1994-01-05
期刊：
影响因子：
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通讯作者：
MCKNEALLY, MF
中科院分区：
文献类型：
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作者：
MAYNE, ST;JANERICH, DT;MCKNEALLY, MF
背景：在美国，大约15%的肺癌死亡病例(每年约22350例死亡)可能不直接归因于吸烟过多。β胡萝卜素的摄入几乎完全来自水果和蔬菜的摄入，这与吸烟者患肺癌的风险降低有关。然而，在不吸烟的人，特别是不吸烟的男性中检验这种联系的研究是有限的。目的：这项研究的目的是检查饮食因素，包括β胡萝卜素和视黄醇是否与非吸烟男性和女性肺癌风险的降低有关。方法：1982年至1985年，纽约州进行了一项以人群为基础的非吸烟者肺癌配对病例对照研究。完成了413对单独匹配的病例对照受试者的饮食访谈。为了确定来自特定食物组的饮食摄入量与肺癌的关系是否因采访类型、吸烟史、性别、年龄或组织类型不同而不同，我们分别检查了来自每个亚组的病例对照数据。β胡萝卜素和视黄醇的摄入量是含有这些营养素的食物每月消费频率的加权总和，其中重量对应于食物中典型部分的营养含量。结果：绿色食品消费(P代表趋势
Background: Approximately 15% of all lung cancer deaths in the United States (about 22350 deaths annually) may not be directly attributable to active cigarette smoking. Consumption of beta carotene, which is derived almost exclusively from intake of fruits and vegetables, has been associated with a reduced risk of lung cancer in smokers. However, studies examining this association in nonsmokers, particularly nonsmoking men, are limited. Purpose: The purpose of this study was to examine whether dietary factors including beta carotene and retinol are associated with a reduced risk for lung cancer in nonsmoking men and women. Methods: A population-based, matched case-control study of lung cancer in nonsmokers was conducted in New York State from 1982 to 1985. Dietary interviews were completed for 413 individually matched case-control pairs of subjects. To determine whether the relationship between dietary intake from specific food groups and lung cancer differed by type of interview, smoking history, sex, age, or histologic type, we examined data on the case-control pairs from each subgroup separately. The intake of beta carotene and retinol was calculated as the weighted sum of the monthly frequencies of consumption of food items containing these nutrients, where the weights correspond to the nutrient content of a typical portion of the food items. Results: Consumption of greens (P for trend