Gain of chromosome region 18q21 including the MALT1 gene is associated with the activated B-cell-like gene expression subtype and increased BCL2 gene dosage and protein expression in diffuse large B-cell lymphoma
Gain of chromosome region 18q21 including the MALT1 gene is associated with the activated B-cell-like gene expression subtype and increased BCL2 gene dosage and protein expression in diffuse large B-cell lymphoma
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DOI：
10.3324/haematol.12057
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发表时间：
2008-04-30
期刊：
影响因子：
10.1
通讯作者：
Siebert, Reiner
中科院分区：
文献类型：
--
作者：
Dierlamm, Judith;Penas, Eva M. Murga;Siebert, Reiner
背景
本研究的目的是确定MALT1基因获得性改变对弥漫性大B细胞淋巴瘤的基因表达和临床参数的影响。
设计与方法
我们通过荧光原位杂交、基于阵列的比较基因组杂交和转录谱分析对116例弥漫性大B细胞淋巴瘤进行了研究。
结果
在44例（38%）中检测到包括MALT1在内的18q21获得性改变，并且其中43例伴有BCL2基因获得性改变。所有18q21/MALT1获得性改变的病例均显示BCL2蛋白表达，而在无18q21/MALT1获得性改变的组中，有79%的病例显示BCL2蛋白表达（p<...此处似乎内容不完整，原英文可能还有后续信息未给出）
BackgroundThe aim of this study was to determine the impact of a gain of the MALT1 gene on gene expression and clinical parameters in diffuse large B-cell lymphoma.Design and MethodsWe analyzed 116 cases of diffuse large B-cell lymphoma by fluorescence in situ hybridization, array-based comparative genomic hybridization, and transcriptional profiling.ResultsA gain of 18q21 including MALT1 was detected in 44 cases (38%) and was accompanied by a gain of BCL2 in 43 cases. All cases with a 18q21/MALT1 gain showed BCL2 protein expression, whereas 79% in the group without a 18q21/MALT1 gain did so (p