Chemical profile of two types of oral snuff tobacco
Chemical profile of two types of oral snuff tobacco
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DOI：
10.1016/s0278-6915(02)00134-5
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发表时间：
2002-11-01
影响因子：
4.3
通讯作者：
Hoffmann, D
中科院分区：
文献类型：
--
作者：
Brunnemann, KD;Qi, J;Hoffmann, D
测定了两种美国品牌的口腔湿鼻烟的化学分析特征。这两个品牌在五个地理位置（美国的纽约州、马萨诸塞州、科罗拉多州、加利福尼亚州和肯塔基州）购买。将它们充分混合以产生代表性样品。品牌A的pH值为5.84，尼古丁含量为0.42%，而品牌B的pH值为7.99，尼古丁含量为2.73%。在pH 5.84时，只有1%的尼古丁以游离碱形式存在，而在pH 7.99时，59%的尼古丁以非质子化形式存在。它是尼古丁的未质子化形式，最容易通过口腔粘膜吸收。鼻烟A含有的水分、硝酸盐、亚硝酸盐和烟草特有的亚硝胺的水平也显著低于鼻烟B。分析肯塔基州大学参比鼻烟1 S3作为外部对照样品。这两种鼻烟品牌目前正在对大鼠进行短期和长期生物测定，以测试烟草特异性N-亚硝胺是口服鼻烟致癌活性的主要贡献者的概念。(C)2002爱思唯尔科技有限公司版权所有。
The chemical-analytical profile of two US brands of oral moist snuff was determined. These two brands were bought in five geographical locations (NY, MA, CO, CA and KY in the US). They were mixed thoroughly to yield representative samples. Brand A had a pH of 5.84 and nicotine content of 0.42%, while brand B had a pH of 7.99 and nicotine content of 2.73%. At pH 5.84, only 1% of the nicotine is present as a free base while 59% of nicotine is present in unprotonated form at pH 7.99. It is the unprotonated form of nicotine that is most readily absorbed through the mucous membrane in the oral cavity. Snuff A contained also significantly lower levels of moisture, nitrate, nitrite and tobacco-specific nitrosamines than snuff B. The University of Kentucky reference snuff 1S3 was analyzed as an external control sample. These two snuff brands are currently being assayed with rats in a short-term and in long-term bioassays to test the concept that the tobacco-specific N-nitrosamines are major contributors to the carcinogenic activity of oral snuff. (C) 2002 Elsevier Science Ltd. All rights reserved.