The HUGO Gene Nomenclature Committee (HGNC)
The HUGO Gene Nomenclature Committee (HGNC)
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DOI：
10.1007/s00439-001-0615-0
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发表时间：
2001-12-01
期刊：
影响因子：
5.3
通讯作者：
Wain, H
中科院分区：
文献类型：
--
作者：
Povey, S;Lovering, R;Wain, H
OMIM、SWISS-PROT、HGMD、GDB、GENATLAS、GeneCards），其中每个符号明确地与单个基因相关联。使用批准的符号大大提高了电子文献检索的效率，我们的数据库确实包括每个批准的符号的所有文献别名，这有助于澄清基因的身份。与小鼠命名委员会（http：//www.信息学. Jax. org/mgihome/nomen/gene. shtml# genenom）确保了绝大多数基因在这两个物种中使用相同的符号（仅大小写不同），通常在其他哺乳动物中也使用相同的符号。最初的目的是给每个基因一个名称，以表明正常基因产物的功能，在可能的情况下仍然这样做，尽管在很多情况下，对序列的了解比对功能的了解更多。优选地，每个符号在基因家族的不同成员中保持平行结构（功能性的或通过序列相关的）。然而，并没有试图在其名称中包含有关基因的所有已知信息;到目前为止，最重要的特征是命名法是唯一的。
OMIM, SWISS-PROT, HGMD, GDB, GENATLAS, GeneCards), where each symbol is unambiguously associated with a single gene. Use of approved symbols greatly increases the efficiency of electronic literature retrieval and our database does include all literature aliases for each approved symbol, which helps to clarify the identity of a gene. Frequent interaction with the mouse nomenclature committee (http://www. informatics. jax. org/mgihome/nomen/gene. shtml# genenom) ensures that for the vast majority of genes the same symbol (differing only in case) is used in the two species and usually also in other mammals.The original aim was to give each gene a name indicating something about the function of the normal gene product and this is still done where possible, although in very many cases more is known about the sequence than its function. In preference, each symbol maintains parallel construction in different members of a gene family (functional or related by sequence). However, there is no attempt to include all known information about a gene in its name; by far the most important feature is that the nomenclature is unique.