Behavioral sensitization to ethanol in rats: evidence from the Sprague-Dawley strain
Behavioral sensitization to ethanol in rats: evidence from the Sprague-Dawley strain
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DOI：
10.1016/s0091-3057(01)00489-0
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发表时间：
2001-04-01
影响因子：
3.6
通讯作者：
Lewis, MJ
中科院分区：
文献类型：
--
作者：
Hoshaw, BA;Lewis, MJ
虽然它已被证明与其他药物的滥用，行为敏化尚未显示与乙醇在大鼠。先前阴性结果的一个可能原因可能是在致敏的不同阶段使用的乙醇剂量。在当前的实验中，远交的Sprague-Dawley大鼠被分为对新奇事物的高反应者和低反应者。通过腹膜内注射生理盐水或1.0 g/kg乙醇预处理15天，然后在3周后给予0.25 g/kg乙醇的激发剂量。在第一个10分钟后的挑战剂量，大鼠高响应新奇预处理乙醇显示较高的自发活动评分相对于其他三组。这些数据证明了乙醇在远交系大鼠中的行为致敏性。(C)2001 Elsevier Science Inc. All rights reserved.
Although it has been shown with other drugs of abuse, behavioral sensitization has not been shown with ethanol in rats. One possible reason for the negative previous findings may be due to the doses of ethanol employed in the different phases of sensitization. In the current experiment, outbred Sprague-Dawley rats were divided into either high or low responders to novelty. They were pretreated for 15 days with intraperitoneal injections of either saline or 1.0 g/kg ethanol, and then given a challenge dose of 0.25 g/kg ethanol after a 3-week period. During the first 10 min after the challenge dose, rats high in response to novelty pretreated with ethanol displayed higher locomotor activity scores relative to the other three groups. These data demonstrated evidence for behavioral sensitization with ethanol in outbred rats. (C) 2001 Elsevier Science Inc. All rights reserved.