Does α1-adrenergic receptor blockade modulate sweating during incremental exercise in young endurance-trained men?
Does α1-adrenergic receptor blockade modulate sweating during incremental exercise in young endurance-trained men?
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DOI：
10.1007/s00421-020-04351-3
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发表时间：
2020-03-27
影响因子：
3
通讯作者：
Kondo, Narihiko
中科院分区：
文献类型：
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作者：
Amano, Tatsuro;Fujii, Naoto;Kondo, Narihiko
目的人外泌汗腺对α 1肾上腺素能受体激动剂有反应。我们最近报道，肾上腺素能机制有助于出汗的耐力训练的男子在递增运动到意志疲劳。然而，尚不清楚这种反应是否由α（1）-肾上腺素能受体激活介导。方法12名受过耐力训练的男子进行递增循环比赛，直到筋疲力尽，同时穿着注水服将皮肤温度限制在34摄氏度左右。测量双侧前臂出汗率，其中远端区域用1%特拉唑嗪（α（1）-肾上腺素能受体拮抗剂）或盐水溶液通过经皮离子电渗疗法在对侧肢体（对照）上处理。我们还测量了未治疗部位的近端双侧前臂出汗率，以确认前臂出汗率没有发生肢体间差异。一旦出汗率在运动后20分钟恢复到运动前的休息水平，则通过离子透入法向皮肤给予0.25%苯肾上腺素（α（1）-肾上腺素能受体激动剂），以验证α（1）-肾上腺素能受体阻滞作用。结果运动期间，未治疗的右前臂和左前臂近端部位的出汗率相似（相互作用，P = 0.581）。同样，与对照部位相比，特拉唑嗪对出汗率没有影响（相互作用，P = 0.848）。运动后给予苯丙氨酸可增加对照部位的出汗率（0.08 +/- 0.09 mg cm（-2）min（-1）），而特拉唑嗪治疗部位的出汗率（0.01 +/- 0.02 mg cm（-2）min（-1））则被抑制了90%（P = 0.026），证实α（1）-肾上腺素能受体阻滞作用未受影响。结论在递增负荷运动过程中，小汗腺α 1肾上腺素能受体与小汗腺出汗无关。
Purpose Human eccrine sweat glands respond to alpha(1)-adrenergic receptor agonists. We recently reported that adrenergic mechanisms contribute to sweating in endurance-trained men during an incremental exercise to volitional fatigue. However, it remains unclear if this response is mediated by alpha(1)-adrenergic receptor activation. Methods Twelve endurance-trained men performed an incremental cycling bout until exhaustion while wearing a water-perfused suit to clamp skin temperature at similar to 34 degrees C. Bilateral forearm sweat rates were measured wherein the distal area was treated with either 1% terazosin (alpha(1)-adrenergic receptor antagonist) or saline solution on the opposite limb (Control) via transdermal iontophoresis. We also measured proximal bilateral forearm sweat rate in untreated sites to confirm that no between-limb differences in forearm sweat rate occurred. Once sweat rate returned to pre-exercise resting levels at similar to 20 min postexercise, 0.25% phenylephrine (alpha(1)-adrenergic receptor agonist) was iontophoretically administered to skin to verify alpha(1)-adrenergic receptor blockade. Results Sweat rates at the proximal untreated right and left forearm sites were similar during exercise (interaction, P = 0.581). Similarly, no effect of terazosin on sweat rate was measured relative to control site (interaction, P = 0.848). Postexercise administration of phenylephrine increased sweat rate at the control site (0.08 +/- 0.09 mg cm(-2) min(-1)), which was suppressed by similar to 90% at the terazosin-treated site (0.01 +/- 0.02 mg cm(-2) min(-1)) (P = 0.026), confirming that alpha(1)-adrenergic receptor blockade was intact. Conclusion Our findings demonstrate that alpha(1)-adrenergic receptors located at eccrine sweat glands do not contribute to eccrine sweating during incremental exercise in young endurance-trained men.