Prognostic factors in acute renal failure due to sepsis. Results of a prospective multicentre study
Prognostic factors in acute renal failure due to sepsis. Results of a prospective multicentre study
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DOI：
10.1093/oxfordjournals.ndt.a027256
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发表时间：
1996-02-01
影响因子：
6.1
通讯作者：
Landais, P
中科院分区：
文献类型：
--
作者：
Neveu, H;Kleinknecht, D;Landais, P
背景脓毒症是住院患者急性肾功能衰竭的主要原因，但其发病率和相关预后因素很少通过多因素分析进行前瞻性评估。我们在20个多学科重症监护病房进行了一项为期6个月的前瞻性研究，以评估因脓毒症导致急性肾功能衰竭住院患者的预后。脓毒症综合征和脓毒性休克的定义是根据社会的危重病医学共识会议的标准。严重程度评分指数（SAPS，APACHE II和失败（OSF））在ICU入院和入选时进行了测量。终点为住院死亡率。157例患者（第1组）的急性肾衰竭有脓毒性起源，包括68例脓毒性休克和89例脓毒症综合征，188例患者（第2组）的急性肾衰竭不是由感染引起的。脓毒性急性肾功能衰竭患者年龄较大（平均年龄：62.2岁vs 57.9岁，P
Background. Sepsis is a major cause of acute renal failure in hospital patients, but its incidence and the associated prognostic factors have rarely been assessed prospectively by multivariate analysis.Methods. We conducted a prospective 6-month study in 20 multidisciplinary intensive care units to assess the prognosis of patients hospitalized with acute renal failure due to sepsis. Sepsis syndrome and septic shock were defined according to the criteria of the Society of Critical Care Medicine Consensus Conference. Severity scoring indexes (SAPS, APACHE II, and failure (OSF)) were measured on ICU admission and on inclusion. The end-point was hospital mortality.Results. Acute renal failure had a septic origin in 157 patients (Group 1), comprising 68 with septic shock and 89 with sepsis syndrome, and did not result from infection in 188 patients (Group 2). Patients with septic acute renal failure were older (mean age: 62.2 versus 57.9 years, P