ADULT AND NEONATAL HUMAN BRAIN - DIFFUSIONAL ANISOTROPY AND MYELINATION WITH DIFFUSION-WEIGHTED MR IMAGING
ADULT AND NEONATAL HUMAN BRAIN - DIFFUSIONAL ANISOTROPY AND MYELINATION WITH DIFFUSION-WEIGHTED MR IMAGING
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DOI：
10.1148/radiology.180.1.2052700
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发表时间：
1991-07-01
期刊：
影响因子：
19.7
通讯作者：
TSUKAMOTO, T
中科院分区：
文献类型：
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作者：
SAKUMA, H;NOMURA, Y;TSUKAMOTO, T
对6名成人志愿者、8名早产儿和3名5-10个月婴儿的脑弥散各向异性进行了临床研究。 采用梯度B为450 sec/mm 2进行弥散加权磁共振成像。 根据白色物质中神经纤维的方向，扩散敏感梯度的方向在x、y和z轴之间改变。 T1和T2加权图像也被用于评估髓鞘形成。 在成年人的白色物质中表现出扩散各向异性。 当梯度平行于白色纤维时，观察到广泛的信号衰减。 相反，在新生儿中，白色物质的扩散各向异性较弱，其中在T1和T2加权图像上没有显示髓鞘形成。 扩散各向异性是更明显的脑成熟后，在成人白色物质中观察到。 弥散各向异性的检测在评价新生儿脑发育和各种白色物质疾病中是有用的。
Diffusional anisotropy of human brain was investigated clinically in six adult volunteers, eight premature neonates, and three infants aged 5-10 months. Diffusion-weighted magnetic resonance imaging was performed with gradient b of 450 sec/mm2. The direction of diffusion-sensitive gradients was changed among x, y, and z axes according to the orientation of neurofibers in white matter. T1-and T2-weighted images also were obtained for evaluation of myelination. Diffusional anisotropy was demonstrated in white matter in the adults. Extensive signal attenuation was observed when gradients were parallel to white matter fibers. Conversely, in neonates, diffusional anisotropy of white matter, in which no myelination was shown on T1- and T2-weighted images, was weak. Diffusional anisotropy was more distinct after brain maturation, as observed in adult white matter. Detection of diffusional anisotropy is useful in evaluating neonatal brain development and various white matter disorders.