SCOP database in 2004: refinements integrate structure and sequence family data
SCOP database in 2004: refinements integrate structure and sequence family data
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DOI：
10.1093/nar/gkh039
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发表时间：
2004-01-01
影响因子：
14.9
通讯作者：
Murzin, AG
中科院分区：
文献类型：
--
作者：
Andreeva, A;Howorth, D;Murzin, AG
蛋白质结构分类（SCOP）数据库是根据其进化和结构关系对所有已知结构的蛋白质进行的综合排序。SCOP中的蛋白质结构域按层次分为家族、超家族、折叠和类。序列和结构数据的不断积累允许更严格的分析，并为理解蛋白质世界及其进化谱提供了重要信息。SCOP参与了一个项目，该项目旨在合理化和整合几个序列和结构数据库中的蛋白质数据。作为该项目的一部分，从1.63版本开始，我们已经开始了SCOP分类的细化，其中引入了许多变化，主要是在超家族以下的级别。即将进行的SCOP重新分类将通过今后的若干版本逐步进行。除了在域条目一级扩大与外部资源的静态链接外，我们还开始更新SCOP的接口能力，以便与其他数据库建立更动态的链接。SCOP可以在http://scop.mrc-lmb.cam.ac.uk/scop上访问。
The Structural Classification of Proteins (SCOP) database is a comprehensive ordering of all proteins of known structure, according to their evolutionary and structural relationships. Protein domains in SCOP are hierarchically classified into families, superfamilies, folds and classes. The continual accumulation of sequence and structural data allows more rigorous analysis and provides important information for understanding the protein world and its evolutionary repertoire. SCOP participates in a project that aims to rationalize and integrate the data on proteins held in several sequence and structure databases. As part of this project, starting with release 1.63, we have initiated a refinement of the SCOP classification, which introduces a number of changes mostly at the levels below superfamily. The pending SCOP reclassification will be carried out gradually through a number of future releases. In addition to the expanded set of static links to external resources, available at the level of domain entries, we have started modernization of the interface capabilities of SCOP allowing more dynamic links with other databases. SCOP can be accessed at http://scop.mrc-lmb.cam.ac.uk/scop.